Heart Surgical Procedures Clinical Trial
Official title:
Late Postconditioning After Cardiac Surgery - Bridge From Surrogate Markers to Clinical Outcome
Retrospective analysis of a 6-month follow up within a randomised controlled study in cardiac surgery with pharmacological postconditioning (sedation on intensive care unit with sevoflurane)
Introduction: In a recent randomized controlled (RCT; NCT00924222) trial the investigators
demonstrated in 102 patients that late post-conditioning with sevoflurane performed in the
intensive care unit (ICU) reduced myocardial injury. These patients presented with lower
troponin T values on the first post-operative day compared with patients undergoing propofol
sedation. In order to assess possible clinical relevant long-term implications in patients
enrolled in this study, the current retrospective analysis is performed focusing on cardiac
and non-cardiac events during the first six months after surgery.
Methods: All patients who had successfully completed the late post-conditioning trial were
included in this follow-up. Primary and secondary endpoints were the proportion of patients
experiencing cardiac and non-cardiac events, respectively. Additionally, therapeutic
interventions such as initiation or change of drug therapy, interventional treatment or
surgery were assessed.
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Time Perspective: Retrospective