Exercise Pulmonary Transit Time

Heart Failure, Diastolic Clinical Trial

Official title:

Echocardiographic Assessment of Pulmonary Transit Time Following Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04336995
• Other study ID #: IRB200429
• Status: Completed
• Phase: Phase 4
• Start date: August 27, 2020
• Est. completion date: March 1, 2024

Study information

• Verified date: April 2024
• Source: Vanderbilt University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study seeks to measure pulmonary transit time via contrast-echocardiography before and after exercise.

Description:

The ability to measure the amount of blood in the lungs using heart-ultrasound (echocardiography) can be useful to estimate how much fluid is in a patient's circulation, which can influence diagnosis and treatment of certain types of heart failure. In some patients, the amount of fluid is normal at rest, but can increase with activity and thus a diagnosis of heart failure can only be made after exercising. Currently, the amount of fluid is measured invasively. We have shown that echocardiography can measure the amount of fluid in the lung circulation at rest without the need for an invasive procedure. We now seek to find out if we can make a similar measurement after exercise. If successful, the need for catheter procedures may be reduced in certain types of heart failure.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: March 1, 2024
• Est. primary completion date: August 25, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Age = 18 years old

2. Able to give informed consent

Exclusion Criteria:

1. Known allergic reaction to Definity or Optison ultrasound contrast

2. Pregnancy/Nursing - as assessed/disclosed by the participant

Related Conditions & MeSH terms

• Heart Failure, Diastolic

Intervention

Diagnostic Test:
• contrast echocardiography
giving echocardiographic contrast and taking echocardiographic images before and after exercise

Locations

Country	Name	City	State
United States	VHVI	Nashville	Tennessee

Sponsors (1)

Lead Sponsor	Collaborator
Vanderbilt University Medical Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pulmonary Transit Time	interval required for the pulmonary blood volume to traverse the pulmonary circulation	3-10 seconds