Rapid Versus Prolonged Inpatient Up-Titration of Captopril

Status Recruiting

Clinical Trial Summary

The primary objective of this study is to establish a safe and effective method of up-titration of captopril for hospital inpatients.

Clinical Trial Description

Angiotensin converting enzyme inhibitors (ACEi) are one of the most frequently prescribed pediatric cardiac medication and overall their safety in children is widely accepted. Pediatric formulary recommendations for ACEi suggest starting with a low initial dose (0.1 mg/kg), to avoid hypotension, and up-titration for a maintenance dose. However, side ranges are quoted for maintenance doses and no guidance is given as to the best method of up-titration, The physician is left uncertain of the optimal dose and how best to achieve it.

The ultimate goal of this study is to be in a position to provide physicians caring for children with heart disease information about how to safely up-titrate this widely used medication, and by doing so to improve dosing in the wider pediatric population. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Heart Disease

Clinical Trial Details

NCT number	NCT00742040
Study type	Interventional
Source	The Hospital for Sick Children
Contact
Status	Recruiting
Phase	Phase 2
Start date	August 2008
Completion date	December 2009

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