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NCT04149730 Clinical Trial

Adrenaline During Resuscitation From Pulseless Electrical Activity

Heart Arrest Clinical Trial

Official title:
Adrenaline During Resuscitation From Pulseless Electrical Activity

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04149730
Other study ID # 2019/785
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 20, 2019
Est. completion date May 15, 2023

Study information
Verified date September 2023
Source St. Olavs Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This is a prospective observational study at St. Olavs hospital in Norway. Data are gathered from defibrillators that have been in use during resuscitation from cardiac arrest. Aim is to investigate the changes in electrocardiograms (ECG) during resuscitation from pulseless electrical activity (PEA), which is a type of cardiac arrest. ECG changes may be useful as a prognostic marker during resuscitation from PEA. In addition the researchers will describe the effect of adrenaline and chest compressions on clinical state transitions during resuscitation from pulseless electrical activity. Clinical state transitions are changes between different types of cardiac arrest. This study is expected to increase our understanding of the dynamics during treatment of cardiac arrest.

Recruitment information / eligibility
Status Completed
Enrollment 280
Est. completion date May 15, 2023
Est. primary completion date January 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: Cardiac arrest among hospitalized patients presenting with PEA as the primary rhythm.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Norway St Olavs Hospital Trondheim
United States Hospital of the University of Pennsylvania Philadelphia Pennsylvania

Sponsors (3)
Lead Sponsor Collaborator
St. Olavs Hospital Norwegian University of Science and Technology, University of Pennsylvania

Countries where clinical trial is conducted

United States,  Norway, 

Outcome
Type Measure Description Time frame Safety issue
Primary QRS frequency Measurement of RR intervals in milliseconds. Every 3 minutes from start till end of cardiopulmonary resuscitation
Primary QRS width Measurement of the width of QRS complexes in milliseconds Every 3 minutes from start till end of cardiopulmonary resuscitation
Primary Changes of clinical states changes of clinical states (for example from Pulseless electrical activity to Ventricular fibrillation) during treatment of cardiac arrest. Every 3 minutes from start till end of cardiopulmonary resuscitation
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