Hearing Loss Clinical Trial
Official title:
Effect of Increased Body Mass Index on Auditory Function
Obesity may directly or indirectly lead to hearing loss
Obesity is measured by Body Mass Index.it is calculated by dividing a person's weight in
kilograms by the square of height in meters. For children and adolescent. Overweight is
defined as Body Mass Index is <85th percentile <95th percentile but obesity is defined as
body mass index at or above the 95th percentile for children and teens of the same age and
sex the increasing in body mass index mass may affect auditory function Directly as adipose
tissue secretes hormones and cytokines, proinflammatory cytokines lead to release of
obesity-induced inflammation which may directly contribute to end-organ damage Also,
Adiponectin, which is thought to have anti-inflammatory and antiatherogenic effects, and
associated with favorable lipoprotein profile, independent of BMI and insulin resistance,
low plasma concentrations of adiponectin have been associated with obesity in children. In
adults, low level of adiponectin has been associated with elevated high-frequency
thresholds.
Indirectly, by obesity comorbidities including Hypertension, Type 2 diabetes mellitus,
Dyslipidemia , Metabolic Syndrome and Cardiovascular Diseases
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