Hearing Loss Clinical Trial
Official title:
Safety of Autologous Human Umbilical Cord Blood Mononuclear Fraction to Treat Acquired Hearing Loss in Children
The objectives of this study are: 1. To see if autologous human umbilical cord blood treatment is safe for children with acquired hearing loss, and 2. To determine if late functional outcome is improved following autologous human umbilical cord blood treatment for children with acquired hearing loss.
Acquired sensorineural hearing loss is characterized by a loss of functioning hair cells in the Organ of Corti, with greater hair cell loss correlating with more severe hearing impairment. Children with sensorineural hearing loss experience difficulty developing normal language which usually leads to poor academic and social development. Currently, there are no reparative therapeutic options available, and treatments are designed to augment the diminished function of the injured Organ of Corti. Pre-clinical data suggest progenitor cell infusions may enhance intrinsic repair mechanisms in the Organ of Corti which may restore hair cells. This treatment could ultimately lead to hearing improvement. Human umbilical cord blood (hUCB) is an available, autologous, stored progenitor cell population available for potential therapeutic use. The primary objective of this study is to determine the safety of autologous hUCB infusion in children with acquired hearing loss. The secondary objective is to determine if functional, physiologic and anatomic outcomes are improved following hUCB treatment in this patient population. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04696835 -
fNIRS in Pediatric Hearing Aids
|
N/A | |
| Completed |
NCT03662256 -
Reducing Childhood Hearing Loss in Rural Alaska Through a Preschool Screening and Referral Process Using Mobile Health and Telemedicine
|
N/A | |
| Completed |
NCT04602780 -
Evaluating the Revised WORQ in CI Users
|
||
| Completed |
NCT03723161 -
Evaluation of the Ponto Bone Anchored Hearing System in a Pediatric Atresia Population
|
||
| Completed |
NCT05086809 -
Investigation of an Updated Bone-anchored Sound Processor
|
N/A | |
| Active, not recruiting |
NCT03548779 -
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
|
N/A | |
| Completed |
NCT03428841 -
Audiovisual Assessment After Dural Puncture During Epidural Placement in Obstetric Patients
|
N/A | |
| Completed |
NCT04559282 -
Home Test of New Sound Processor
|
N/A | |
| Enrolling by invitation |
NCT03345654 -
Individually-guided Hearing Aid Fitting
|
||
| Completed |
NCT06016335 -
MRI-based Synthetic CT Images of the Head and Neck
|
N/A | |
| Completed |
NCT05165121 -
Comparison of Hearing Aid Fitting Outcomes Between Self-fit and Professional Fit for MDHearing Smart Hearing Aids
|
N/A | |
| Recruiting |
NCT05533840 -
Establishment and Application of a New Imaging System for Otology Based on Ultra-high Resolution CT
|
||
| Terminated |
NCT02294812 -
Effects of Cognitive Training on Speech Perception
|
N/A | |
| Completed |
NCT04622059 -
AUditive Direct In-utero Observation (AUDIO): Prenatal Testing of Congenital Hypoacusis
|
N/A | |
| Recruiting |
NCT02558478 -
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing
|
N/A | |
| Withdrawn |
NCT02740322 -
Validating the Hum Test
|
N/A | |
| Completed |
NCT01963104 -
Community-Based Kiosks for Hearing Screening and Education
|
N/A | |
| Completed |
NCT01857661 -
The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial
|
N/A | |
| Completed |
NCT01892007 -
Evaluation of Cogmed Working Memory Training for Adult Hearing Aid Users
|
N/A | |
| Withdrawn |
NCT01223638 -
The Prevalence of Hearing Loss Among Children With Congenital Hypothyroidism
|
N/A |