Hearing Loss Clinical Trial
Congenital hypothyroidism (CH) occurs in 1:4000 live births. Neurological disturbances like
speech delay, motor delay and lower IQ were reported in children with CH. Evidence from
animal experiments indicate that CH is associated with high frequency of deafness.
Morphological changes of the external and internal cholera hairs were reported in mutagenic
mice with CH. Anatomical changes of the internal ear and low hearing threshold were reported
in mice bearing Dual oxidase 2 (Duox2) gene mutations, which is responsible of oxidation of
iodide. Knockout of Pax8 gene in mice resulted in both agenesis of thyroid gland and
deafness. Early L-thyroxin therapy prevented the development of deafness in those mice. The
expression of thyroid receptor α (TRα) in the external and internal cholera hairs in mice
indicates that the thyroid hormones have an important role in the development of the
internal ear.
The etiology of deafness in human is both genetic and environmental. The prevalence of
deafness in live births is 1:1000 and among them 60% is genetic. Connexin 26 gene mutations
are the most common cause of inherited deafness and account for about 40% of the genetic
cases. In two conditions in human the coexistence of hypothyroidism and deafness were
reported; Pendred syndrome and thyroid hormone resistance syndrome.
The prevalence of hearing loss in human with CH was explored in only few studies and the
results are contrary.
The aim of the current study is to study the prevalence of hearing loss among children with
CH and to compare the clinical, biochemical and genetic characteristics between subjects
with hearing loss to those without hearing loss.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | June 2015 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 2 Years to 30 Years |
Eligibility |
Inclusion Criteria: - Patients with congenital hypothyroidism aged 2-30 years Exclusion Criteria: - Hearing defects in the family - Intrauterine infections - Perinatal hypoxia - Long term therapy with aminoglycosides - Acoustic trauma in the past |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Israel | Ha'Emek Medical Center | Afula |
Lead Sponsor | Collaborator |
---|---|
HaEmek Medical Center, Israel |
Israel,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hearing Level | 2 years | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04696835 -
fNIRS in Pediatric Hearing Aids
|
N/A | |
Completed |
NCT03662256 -
Reducing Childhood Hearing Loss in Rural Alaska Through a Preschool Screening and Referral Process Using Mobile Health and Telemedicine
|
N/A | |
Completed |
NCT04602780 -
Evaluating the Revised WORQ in CI Users
|
||
Completed |
NCT03723161 -
Evaluation of the Ponto Bone Anchored Hearing System in a Pediatric Atresia Population
|
||
Completed |
NCT05086809 -
Investigation of an Updated Bone-anchored Sound Processor
|
N/A | |
Active, not recruiting |
NCT03548779 -
North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2
|
N/A | |
Completed |
NCT03428841 -
Audiovisual Assessment After Dural Puncture During Epidural Placement in Obstetric Patients
|
N/A | |
Completed |
NCT04559282 -
Home Test of New Sound Processor
|
N/A | |
Enrolling by invitation |
NCT03345654 -
Individually-guided Hearing Aid Fitting
|
||
Completed |
NCT06016335 -
MRI-based Synthetic CT Images of the Head and Neck
|
N/A | |
Completed |
NCT05165121 -
Comparison of Hearing Aid Fitting Outcomes Between Self-fit and Professional Fit for MDHearing Smart Hearing Aids
|
N/A | |
Recruiting |
NCT05533840 -
Establishment and Application of a New Imaging System for Otology Based on Ultra-high Resolution CT
|
||
Completed |
NCT04622059 -
AUditive Direct In-utero Observation (AUDIO): Prenatal Testing of Congenital Hypoacusis
|
N/A | |
Terminated |
NCT02294812 -
Effects of Cognitive Training on Speech Perception
|
N/A | |
Recruiting |
NCT02558478 -
Identification of New Genes Implicated in Rare Neurosensory Diseases by Whole Exome Sequencing
|
N/A | |
Withdrawn |
NCT02740322 -
Validating the Hum Test
|
N/A | |
Completed |
NCT01963104 -
Community-Based Kiosks for Hearing Screening and Education
|
N/A | |
Completed |
NCT01892007 -
Evaluation of Cogmed Working Memory Training for Adult Hearing Aid Users
|
N/A | |
Completed |
NCT01857661 -
The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial
|
N/A | |
Active, not recruiting |
NCT01225978 -
Refining Information Technology Support for Genetics in Medicine
|
N/A |