NCT03546712 - Clinical Trial References

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Citation(s)

Ackerley R, Carlsson I, Wester H, Olausson H, Backlund Wasling H
Touch perceptions across skin sites: differences between sensitivity, direction discrimination and pleasantness. Front Behav Neurosci. 2014 Feb 19;8:54. doi: 10.3389/fnbeh.2014.00054. eCollection 2014.
Chai G, Sui X, Li S, He L, Lan N
Characterization of evoked tactile sensation in forearm amputees with transcutaneous electrical nerve stimulation. J Neural Eng. 2015 Dec;12(6):066002. doi: 10.1088/1741-2560/12/6/066002. Epub 2015 Sep 24.
Croy I, Sehlstedt I, Wasling HB, Ackerley R, Olausson H
Gentle touch perception: From early childhood to adolescence. Dev Cogn Neurosci. 2019 Feb;35:81-86. doi: 10.1016/j.dcn.2017.07.009. Epub 2017 Aug 18.
Harvie DS, Kelly J, Buckman H, Chan J, Sutherland G, Catley M, Novak J, Tuttle N, Sterling M
Tactile acuity testing at the neck: A comparison of methods. Musculoskelet Sci Pract. 2017 Dec;32:23-30. doi: 10.1016/j.msksp.2017.07.007. Epub 2017 Jul 29.
Pinto JM, Kern DW, Wroblewski KE, Chen RC, Schumm LP, McClintock MK
Sensory function: insights from Wave 2 of the National Social Life, Health, and Aging Project. J Gerontol B Psychol Sci Soc Sci. 2014 Nov;69 Suppl 2:S144-53. doi: 10.1093/geronb/gbu102.
Rigato S, Banissy MJ, Romanska A, Thomas R, van Velzen J, Bremner AJ
Cortical signatures of vicarious tactile experience in four-month-old infants. Dev Cogn Neurosci. 2019 Feb;35:75-80. doi: 10.1016/j.dcn.2017.09.003. Epub 2017 Sep 14.

Standard References Norms for Tactile Localization Acuity in Upper Limb Among the Asymptomatic Middle School Children: A Normative Research

Clinical trial NCT03546712 - References