Effect of CYP2C9*3 Polymorphism on Ibuprofen in Pakistani Population

Status Completed

Clinical Trial Summary

The goal of this Observational study was to identify the effect of CYP2C9 gene polymorphism in the Pakistani population. The main question it aims to answer were: - to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen - to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction.

Clinical Trial Description

The goal of this observational study was to identify the effect of CYP2C9*3 gene polymorphism in the Pakistani population, due to the high prevalence of this variant in the Pakistani Population The main question it aims to answer were: - to evaluate the effect of this genetic polymorphism on the clinical efficacy of Ibuprofen - to evaluate the effect of this genetic polymorphism on the clinical tolerability of Ibuprofen Participants were prescribed Ibuprofen after molar tooth extraction. The blood samples of the participants were taken and further genotyping was performed using conventional tetraARMS PCR. The results were visualized by gel electrophoresis. ;

Study Design

Related Conditions & MeSH terms

Healthy Volunteers

Clinical Trial Details

NCT number	NCT05983042
Study type	Observational
Source	Riphah International University
Contact
Status	Completed
Phase
Start date	November 1, 2022
Completion date	July 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05001152` - Taste Assessment of Ozanimod	Phase 1
Completed	`NCT05029518` - 3-Way Crossover Study to Compare the PK (Pharmokinetics) and to Evaluate the Effect of Food on the Bioavailability	Phase 1
Completed	`NCT04493255` - A Study to Determine the Metabolism and Elimination of [14C]E7090 in Healthy Male Participants	Phase 1
Completed	`NCT03457649` - IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers	Phase 1
Completed	`NCT00995891` - Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies
Completed	`NCT05043766` - Evaluation of Oral PF614 Relative to OxyContin	Phase 1
Completed	`NCT05050318` - Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively	Phase 4
Completed	`NCT04466748` - A Multiple Ascending Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects	Phase 1
Completed	`NCT00746733` - Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC	Phase 1
Recruiting	`NCT05929651` - Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy	Phase 4
Completed	`NCT05954039` - Evaluation of the Efficacy of a Dietary Supplement on Hair Loss and Hair Aspect	N/A
Completed	`NCT05045716` - A Study of Subcutaneous Lecanemab in Healthy Participants	Phase 1
Active, not recruiting	`NCT02747927` - Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children	Phase 3
Completed	`NCT05533801` - A Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants	Phase 1
Not yet recruiting	`NCT03931369` - Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)	Phase 2
Completed	`NCT03279146` - A Single Dose Study Evaluating PK of TXL Oral Formulations in Healthy Subjects	Phase 1
Completed	`NCT06027437` - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants	Phase 1
Recruiting	`NCT05619874` - Effects of Two Virtual HIFCT Programs in Adults With Abdominal Obesity	N/A
Completed	`NCT05553418` - Investigational On-body Injector Clinical Study	N/A
Completed	`NCT04092712` - Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers	Phase 1