| Eligibility |
Inclusion Criteria:
- Participant must be 18 to 50 years of age, inclusive, at the time of signing the
informed consent.
- Participants who are overtly healthy as determined by medical evaluation including
medical history, physical examination, clinical laboratory tests, vital sign
measurements, and 12-lead electrocardiogram results. A participant with a clinical
abnormality or laboratory parameters outside the reference range may be included only
if the investigator feels and documents that the finding is unlikely to introduce
additional risk factors and will not interfere with the study procedures.
- Body weight more than or equal to (>=) 50.0 kilograms (kg) (110 pound) for males and
>=45 kg (99 pound) for females and body mass index within the range 18.5 to 32.0
kilogram per square meters (kg/m^2) (inclusive).
- Male or Female: Contraceptive use by men or women should be consistent with local
regulations regarding the methods of contraception for those participating in clinical
studies. a. Male participants: Male participants are eligible to participate if they
agree to the following during the study intervention period until completion of the
follow-up visit: Refrain from donating sperm PLUS, either: Be abstinent from
heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long
term and persistent basis) and agree to remain abstinent OR Must agree to use
contraception/barrier as detailed below: Agree to use a male condom with female
partner and should also be advised of the benefit for a female partner to use a highly
effective method of contraception, as a condom may break or leak when having sexual
intercourse with a woman of childbearing potential (WOCBP) who is not currently
pregnant. Agree to use a male condom when engaging in any activity that allows for
passage of ejaculate to another person. b. Female participants: A female participant
is eligible to participate if she is not pregnant or breastfeeding, and 1 of the
following conditions applies: Is not a WOCBP OR Is a WOCBP and using a contraceptive
method that is highly effective, with a failure rate of less than (<) 1 percent (%),
for at least 30 days prior to dosing until completion of the follow up visit. The
investigator should evaluate the potential for contraceptive method failure (e.g.,
noncompliance, recently initiated) in relationship to the first dose of study
intervention. A WOCBP must have a negative highly sensitive pregnancy test (urine or
serum as required by local regulations) before the first dose of study intervention.
The investigator is responsible for review of medical history, menstrual history, and
recent sexual activity to decrease the risk for inclusion of a woman with an early
undetected pregnancy.
- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the informed consent form and in this
protocol.
Exclusion Criteria:
- History or presence of or current cardiovascular, respiratory, hepatic, renal,
gastrointestinal, endocrine, hematological, or neurological disorders capable of
significantly altering the absorption, metabolism, or elimination of drugs,
constituting a risk when taking the study intervention, or interfering with the
interpretation of data.
- Abnormal blood pressure as determined by the investigator or designee
- Any surgical or medical condition (active or chronic) that may interfere with drug
absorption, distribution, metabolism, or excretion of the study intervention, or any
other condition that may place the participant at risk, in the opinion of the
investigator.
- Positive test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at
screening.
- Use of any systemic antibiotic within 30 days of screening.
- Within 2 months before screening, either a confirmed history of Clostridium difficile
diarrhea infection or a past positive of Clostridium difficile toxin test.
- Current or chronic history of liver disease or known hepatic or biliary abnormalities
(with the exception of Gilbert syndrome or asymptomatic gallstones).
- History of drug and/or alcohol abuse within 6 months before screening, as determined
by the investigator, or has a positive drug screen at screening or upon admission to
the clinic.
- History of sensitivity/hypersensitivity to any of the study drugs, components thereof,
or a history of drug or other allergy that, in the opinion of the investigator or the
GlaxoSmithKline medical monitor contraindicates their participation.
- History of sensitivity to heparin or heparin-induced thrombocytopenia (if the clinic
uses heparin to maintain intravenous cannula patency).
- Impaired sense of taste or smell, in the opinion of the investigator.
- Participants must abstain from taking prescription or non-prescription drugs (except
for hormonal contraceptives and/or acetaminophen [up to 2 grams per day]), vitamins,
and dietary or herbal supplements, within 7 days (or 14 days if the drug is a
potential enzyme inducer) or 5 half-lives (whichever is longer) prior to study
intervention until completion of the follow-up visit, unless, in the opinion of the
investigator and sponsor, the medication will not interfere with the study.
- Participants must abstain from taking QT-prolonging drugs or drugs known to increase
the risk of torsades de pointes or the participant is taking a strong cytochrome P450
enzyme 3A4 (CYP3A4) inhibitor within 7 days or 5 half-lives (whichever is longer).
- Previous exposure to gepotidacin within 12 months prior to starting study intervention
- Participant has participated in a clinical trial and has received an investigational
product prior to gepotidacin administration within 30 days, 5 half-lives, or twice the
duration of the biological effect of investigational product (whichever is longer).
- Participant has participated in a clinical trial with frequent blood sampling and/or
sampling blood volumes that in total may reached an extracted blood volume above 7
milliliter per kilogram (mL/kg) (i.e., approximately 500 milliliter (mL) for a 70 kg
participant) within the previous 56 days prior to informed consent.
- Presence of hepatitis B surface antigen or positive hepatitis C antibody test result
at screening or within 3 months prior to starting study intervention.
- Alanine aminotransferase (ALT) more than (>)1.5 * upper limit of normal (ULN) at
screening or check-in.
- Bilirubin >1.5 * ULN (isolated bilirubin >1.5 * ULN is acceptable if bilirubin is
fractionated and direct bilirubin <35%) at screening or check-in.
- History of any kidney disease or current or chronic history of impaired renal function
as indicated by an estimated creatinine clearance <60 milliliter per minute (mL/min).
- A positive test for human immunodeficiency virus antibody.
- History of regular alcohol consumption within 6 months of screening defined as an
average weekly intake of >21 units (or an average daily intake of >3 units) for males
or an average weekly intake of >14 units (or an average daily intake >2 units) for
females. One unit is equivalent to 270 mL of full-strength beer, 470 mL of light beer,
30 mL of spirits, or 100 mL of wine.
- Urinary cotinine level indicative of smoking or history of regular use of tobacco- or
nicotine-containing products within 3 months of screening.
- Clinically significant abnormal findings in serum chemistry, hematology, or urinalysis
results obtained at screening or check-in (Day-1).
- Baseline QTcF of >450 milliseconds (msec) at screening or check-in (Day-1).
|
