MRI Study of Saccadic Adaptation

Healthy Volunteers Clinical Trial

Official title:

Coupling Between Saccadic Adaptation and Visuospatial Perception Process: MRI Study in Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03488082
• Other study ID #: 69HCL18_0200
• Secondary ID: 2018-A00932-53
• Status: Completed
• Phase: N/A
• Start date: October 17, 2018
• Est. completion date: July 17, 2020

Study information

• Verified date: January 2022
• Source: Hospices Civils de Lyon
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections).

The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: July 17, 2020
• Est. primary completion date: July 17, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Age: 18 to 40 years included,

Exclusion Criteria:

• Known ophthalmological or neurological pathology,

• Non-stabilized medical condition,

• Taking psychotropic treatment,

• No fluency in reading in French,

• Pregnant and / or breastfeeding woman

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Behavioral:
• fMRI
saccadic adaptation (target presentations, with or without target jump) during fMRI exam

Locations

Country	Name	City	State
France	Inserm U1208	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	BOLD signal	cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks).	throughout the behavioral experiment at Day 1
Secondary	Eye movements	measurement of the eye movements (saccades) of the subject while fixating and shifting gaze toward visual targets (behavioral tasks).	during the development of saccadic adaptation (throughout the behavioral experiments at Day 1)