Healthy Volunteers Clinical Trial
Official title:
Effect of Intragastric Administration of Fatty Acids on Generalized Reward Sensitivity
This study aim to investigate the influence of intragastrically infused fatty acid on the generalization of responses to reward within the food domain and between financial and sexual domains.
Earlier research at the Faculty of Economics and Business (FEB) has demonstrated
generalization of reward sensitivity after sensory stimulation in a different domain. As
increased sensory stimulation in the sexual domain (Van den Bergh et al. 2008) or the power
domain (Briers et al. 2007), the preference for immediate small financial reward increased
deferred pay. Hongda, DeWitte & Warlop (2008) were able to neutralize this effect by
domain-specific financial satiation. In this research, The investigators investigate the
possible influence of (subliminal) intragastric administration of fatty acids in reward
sensitivity in the power domain, and whether this effect generalizes to financial and sexual
domain. Previous research at the Translational Research Center for Gastrointestinal
Disorders (TARGID) showed that such administration can neutralize the effects of
mood-priming (Van Oudenhove et al., 2011). This study aims to examine the implications of
those findings in the motivational domain.
60 healthy heterosexual men come to the lab twice, once for the fatty acid condition, once
for the control condition (counterbalanced, and randomly assigned to sequence condition). In
each session the same dv's are measured (first three tasks counterbalanced, progressive
ratio task always at the end). At the end of the second session, participants also compete a
series of interindividual difference measures (scales).
This research forms the start of a collaboration between TARGID and the Center for Research
in Marketing and Consumer Science at KU Leuven Faculty of Business and Economics. The
current paradigm is largely based on an earlier study by Prof. Dr. Lukas Van Oudenhove
showing the effect of intragastric administration of an identical fatty acid solution tested
for mood regulation (Van Oudenhove et al., 2011). The procedure performed in this study,
which is placing a thin nasogastric tube is frequently used in the TARGID research and other
research and is absolutely proven to be safe, with no mention of any adverse reactions
during numerous previous studies. Similar studies by our research group had already been
approved by the Medical Ethics Committee, and as always sees Prof. Tack ensure that the
study conducted by researchers who have received adequate training and have acquired
sufficient experience in this specific procedure before the start of the study. The
procedure can be carried out in healthy volunteers in a perfectly safe manner.
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