Healthy Volunteers Clinical Trial
Official title:
A Randomized, Double-Blind, Placebo-Controlled, Ascending Dose Study to Assess the Safety, Tolerability, and Pharmacodynamic Effects of REGN2477 Alone and in Combination With REGN1033 in Healthy Postmenopausal Women and Healthy Adult Men
The primary objective is to assess the safety and tolerability of REGN2477 alone and combined
with REGN1033.
The secondary objectives are to:
- Assess the effect of REGN2477 alone, REGN1033 alone, and REGN2477 + REGN1033 in
combination on thigh muscle volume
- Assess the effects of REGN2477 alone, REGN1033 alone, and REGN2477 + REGN1033 in
combination on total and regional body composition
- Evaluate the Pharmacokinetic (PK) profile of REGN2477 and REGN1033
- Assess immunogenicity of REGN2477 or REGN1033
- Assess REGN2477 or REGN1033 target engagement
n/a
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