Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device

Healthy Volunteers Clinical Trial

— RC-TMS  

Official title:

Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02596789
• Other study ID #: 2012-A00316-37
• Status: Completed
• Phase: N/A
• First received: July 23, 2014
• Last updated: May 3, 2017
• Start date: June 2012
• Est. completion date: June 2016

Study information

• Verified date: May 2017
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study has two main goals :

• to investigate the impact of aging on cortical excitability (CE)

• to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.

A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 75
• Est. completion date: June 2016
• Est. primary completion date: June 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• male or female

• age 18-75

• signed informed consent

• normal physical examination

Exclusion Criteria:

• less 18 or more 75 years of age

• contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before

• severe physical disease

• treatment with psychotropic drugs

• overt psychiatric disease

• alcohol consumption before the examination

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Device:
• TMS "Magpro®, Magventure Inc" device

Locations

Country	Name	City	State
France	Department of Psychiatry & Neurology - University Hospital Grenoble	Grenoble

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.	Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations.; Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.	Participants will be followed for an expected average of one month
Primary	Durations of Cortical Silent Period (ms)	Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.	Participants will be followed for an expected average of one month