Human Oral Detection of Glucose Olygomers

Healthy Volunteers Clinical Trial

Official title:

The Role of Salivary Contents in Taste Perception of Starch and Its Hydrolysis Products

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02589353
• Other study ID #: IRB # 5373
• Status: Completed
• Phase: Phase 4
• Start date: April 21, 2017
• Est. completion date: February 16, 2023

Study information

• Verified date: February 2023
• Source: Oregon State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 157
• Est. completion date: February 16, 2023
• Est. primary completion date: December 16, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• self-reported healthy adults between the ages of 18-60 who are fluent in English.

Exclusion Criteria:

• adults 61 years old and above

• smokers

• pregnant women

• taking any prescription pain/ insulin medication

• has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)

• has current oral lesions, canker sores, or piercings

• has a history of food allergy

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Drug:
• Acarbose
Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain ~484 microgram acarbose; total maximum exposure of each subject to acarbose will be ~14-30 mg each session (1-20 sessions)

Locations

Country	Name	City	State
United States	Department of Food Science and Technology	Corvallis	Oregon

Sponsors (1)

Lead Sponsor	Collaborator
Oregon State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Detection of glucose polymers in the presence of acarbose	There is only one outcome measure, that is the detection of glucose polymers. Subjects will be asked to discriminate a target sample (glucose polymers). Three samples will be applied using cotton swabs on the subjects' tongue (one at a time): 2 blanks (water + acarbose) and 1 target stimuli (glucose polymer solution + acarbose). Subjects will be asked to identify the target sample. The number of subjects who correctly identify the target stimuli will be counted and will be statistically analyzed to determine whether glucose polymer can be detected without the confounding effect of salivary alpha amylase hydrolysis.	up to 5 years