Healthy Volunteers Clinical Trial
Official title:
Urinary Alkylresorcinol Metabolites as a Biomarker of Whole Grain Wheat and Rye Intake
Alkylresorcinols (AR) are a group of lipids found in the bran fraction of wheat and rye
grains. AR are absorbed into the bloodstream and their metabolites are excreted in urine in
measurable amounts following ingestion of wholegrain (WG) wheat or rye cereal. As AR are
absent in refined cereals, plasma AR and urinary AR metabolites are proposed as suitable
biomarkers of dietary intake of WG wheat and rye cereal, with a number of studies supporting
this proposal. Different AR species are present in characteristic quantities in WG wheat in
comparison to WG rye cereals, which can allow identification of the main source of WG (wheat
or rye) in individuals by analysing the AR concentrations in blood. However the patterns of
urinary AR metabolite excretion following wheat or rye intake have not yet been investigated
to determine if there are differences according to WG source.
The present study aims to:
(i) investigate the differences in AR metabolite excretion pattern in spot and 24 hour urine
samples after following a predominantly WG rye-based diet in comparison to a predominantly
WG wheat-based diet and in comparison to control (refined cereal diet) (ii) compare the
validity and reproducibility of AR metabolites in spot urine samples in comparison to 24
hour urine samples.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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