Healthy Volunteers Clinical Trial
Official title:
A Randomised, Crossover, Relative Bioavailability Study of Nicotine Delivered by an Electronic Vapour Product, a Nicotine Inhalator and a Conventional Cigarette
Electronic Vapour Products (EVPs) are a relatively new class of consumer products that are
otherwise known as electronic cigarettes. These may look like conventional cigarettes but do
not contain tobacco.
The 'vapour' produced by such devices typically consists of humectants (propylene glycol or
glycerol), nicotine, water, and flavours.
This trial is to evaluate the pharmacokinetic profile of an EVP.
The principal part of this study evaluates the nicotine pharmacokinetic profile of
conventional cigarettes, a nicotine inhalator, an unflavoured EVP and a flavoured EVP.
A second part investigates the nicotine delivery of an EVP with four different nicotine
doses.
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Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label
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