Healthy Volunteers Clinical Trial
Official title:
Safety and Immunogenicity Following Further Boosting With HIV-1 MVA-CMDR Vaccine to HIVIS03 Volunteers Who Were Primed With HIV-1 DNA Low Dose Intradermally or 'Standard' Dose Intramuscularly and Boosted With MVA-CMDR Vaccine
The purpose of the study is to determine the safety and immunogenecity of a third MVA in the
HIVIS 03 volunteers who have received 3 HIVIS DNA vaccines followed by boosting with 2 MVA
vaccines.
The investigators postulate that the Immune responses that were observed in the HIVIS 03
trial are likely to wane over time. To date it is unknown how these responses should best be
maintained. In this study the investigators seek to boost immune responses, especially the
antibody responses induced by the second MVA boost.
Since the HIV specific antibodies were induced only after the second MVA injection, it is
hypothesized that a 3rd MVA will give rise to even higher and sustained antibody titers.
n/a
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label
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