Healthy Volunteers Clinical Trial
Official title:
Bioavailability and Anti-inflammatory Activities of Mangostins: a Pilot Study
Mangosteen is a tropical tree. The peel of mangosteen fruit is used in traditional medicine. The purpose of this study was to determine the bioavailability of the xanthones from mangosteen juice in adult human subjects.
Garcinia mangostana L. (mangosteen) is a tropical tree native to Southeast Asia. The
pericarp of mangosteen fruit is used in traditional medicine to treat inflammation,
infections, wounds, and diarrhea. The proposed health-promoting effects have been attributed
to a family of polyphenols referred to as xanthones. Since its introduction into the United
States, juices and products containing mangosteen fruit have become a top-selling botanical
dietary supplement. This commercial success largely has been the result of aggressive
marketing of health claims based on in vitro observations and anecdotal reports.
The purpose of this study was to determine the bioavailability of xanthones from mangosteen
juice in adult human subjects. After an overnight fast of at least 10h, male and female
subjects were admitted to the Ohio State University Clinical Research Center. Volunteers
ingested 2 ounces of 100% mangosteen juice as part of a western-style breakfast. Pericarp
particles accounted for 1% of the mass and 99% of total xanthone content in the juice. This
dose provided 130 ± 2 mg total xanthones. Blood was collected prior to breakfast and
1,2,3,4,6,8 and 24h. Subjects were fed a mangosteen-free lunch and released from the unit
after the 8h collection, refraining from mangosteen containing products until final
collection of blood at 24h. Urine was collected for the 24 test period.
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