Phase 1 Study to Evaluate the PK, Safety, Tolerability of BIIB023 in Chinese, Japanese, and Caucasian Healthy Volunteers

Healthy Volunteers Clinical Trial

Official title:

A Single-Dose, Randomized, Double-Blind, Parallel-Group, Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BIIB023 in Chinese, Japanese, and Caucasian Adult Healthy Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01407406
• Other study ID #: 211HV102
• Status: Completed
• Phase: Phase 1
• First received: July 14, 2011
• Last updated: September 12, 2013
• Start date: September 2011
• Est. completion date: February 2012

Study information

• Verified date: March 2012
• Source: Biogen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Australia: Department of Health and Ageing Therapeutic Goods AdministrationHong Kong: Department of HealthAustralia: Human Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Rationale for the Study: Phase 1 pharmacokinetic (PK) data is needed in Chinese and Japanese populations to support future clinical development of BIIB023 in China and Japan.

Study Design: This is a single-dose study to assess the PK, safety, and tolerability of BIIB023 administered intravenously (IV) to adult Chinese, Japanese, and Caucasian healthy volunteers. The Caucasian group is included to allow comparison of PK data from different groups using data from the same study under the same controlled conditions.

Subjects will be in the clinic for 48 hours around the time of dosing and in the study for up to 100 days.

Description:

Rationale for the Study: Phase 1 pharmacokinetic (PK) data is needed in Chinese and Japanese populations to support future clinical development of BIIB023 in China and Japan.

Study Design: This is a single-dose, Randomized, Double-Blind, parallel-group study to evaluate the PK, safety, and tolerability of BIIB023 administered intravenously (IV) to adult Chinese, Japanese, and Caucasian healthy volunteers. The Caucasian group is included to allow comparison of PK data from different groups using data from the same study under the same controlled conditions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: February 2012
• Est. primary completion date: February 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Must have the ability to understand the purpose and risks of the study & provide signed & dated informed consent.

• Chinese, Japanese or Caucasian subjects

• Subjects of childbearing potential must practice effective contraception during the study and 3 months after their last dose of study treatment.

• Must have a BMI within the range of 18.5 to 25 kg/m2.

• Must be willing to abstain from using tobacco and tobacco-containing products during the in-clinic period.

• Must be willing to limit alcohol intake to no more than 2 units per day throughout the duration of the study (with some stricter exceptions at various timepoints).

• Must be deemed healthy as determined by the Investigator, based on assessments at Screening and Day -1.

Exclusion Criteria:

• Known to have a positive test result for Human Immunodeficiency Virus (HIV) antibody.

• Known history of hepatitis C or hepatitis B virus.

• History of tuberculosis (TB) or a positive QuantiFERON®-TB Gold test.

• Subjects with a history of carcinoma in situ and malignant disease. (with the exception of basal cell carcinoma that has been completely excised prior to study)

• History of clinically important severe allergic or anaphylactic reactions.

• Known allergy to components of the BIIB023 formulation.

• History of any clinically important cardiac, endocrinologic, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, and renal, or other major disease, as determined by the Investigator.

• Abnormal hematology or blood chemistry values at Screening or Day -1, as determined by the Investigator.

• Serious infection (e.g., pneumonia, septicemia) within the 2 months prior to Screening.

• History of drug or alcohol abuse (as defined by the Investigator) within 6 months prior to screening, and/or a positive urine drug screen (without a medically indicated rationale) or positive alcohol breath test at Screening or on Day -1.

• Active bacterial or viral infection and fever >38°C within 48 hours prior to study treatment administration.

• Female subjects who are pregnant, currently breastfeeding, or attempting to conceive during the study.

• Surgery within 3 months prior to Day -1 or any surgical procedure planned during the course of the study

• Previous exposure to BIIB023.

• Treatment with another investigational drug , device, or approved therapy for investigational use within 30 days prior to Day -1, or 7 half lives of the investigational product, whichever is longer

• Treatment with any prescription medication within 2 weeks before Day -1 with the exception of oral contraceptives for women of childbearing potential.

• Treatment with any nonprescription medicinal products (including vitamin/mineral/herbal containing preparations but excluding acetaminophen) within the 7 days prior to study treatment.

• Vaccination within 4 weeks of study treatment.

• Blood donation (1 unit or more) within 1 month prior to study treatment or plasma donation within 7 days prior to study treatment.

• Alcohol use within 48 hours prior to study treatment or during the In-Clinic period.

• Current enrollment in any other study treatment or disease study.

• Inability to comply with study requirements.

• Vigorous exercise (as determined by the Investigator) within 72 hours prior to any study visit.

• Other unspecified reasons that, in the opinion of the Investigator or Biogen Idec, make the subject unsuitable for enrollment.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Drug:
• BIIB023 - low dose IV Dose

• BIIB023 - high dose IV Dose

Locations

Country	Name	City	State
Australia	Research Site	Melbourne	Victoria
China	Research Site	Hong Kong	Hong Kong

Sponsors (1)

Lead Sponsor	Collaborator
Biogen

Countries where clinical trial is conducted

Australia,  China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	AUC of BIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Primary	Cmax of BIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Primary	Tmax of BIIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Primary	Half-life of BIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Primary	Volume of distribution of BIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Primary	Clearance of BIIB023		Participants will be followed for the duration of a study; an expected 71 days	No
Secondary	Number of patients with Adverse Events as a measure of safety and tolerability		Participants will be followed for the duration of a study; an expected 71 days	No
Secondary	Number of patients with Serious Adverse Events as a measure of safety and tolerability		Participants will be followed for the duration of a study; an expected 71 days	No