Healthy Volunteers Clinical Trial
Official title:
Investigation of Cortico-Rectal Pathways in Healthy Subjects and Constipated Patients
Biofeedback therapy improves bowel symptoms and anorectal function in patients with dyssynergic defecation, however its mechanism of action is not known. The investigators hypothesize that biofeedback therapy enhances gut-brain-gut communication by altering cortical processing of information and improving cortically mediated neuromuscular function of the gut. However, in order to better understand these mechanisms in patients, the investigators need to examine and establish normative data and compare findings with healthy subjects. The investigators specific aims are to examine and evaluate the following 40 normal subjects; (1) To evaluate the afferent cortical evoked potentials in response to the electrical stimulation of the anorectum and (2) To evaluate the corticofugal tracts (efferent) by recording the anal and rectal electromyographic responses following noninvasive lumbosacral and transcranial magnetic stimulation.
1. Cortical evoked potentials:A probe with 2 ring electrodes is placed in anus and rectum.
A small amount of electrical current is passed. The cortical evoked responses to the
anal and rectal electrical stimulation is measured from the scalp using a
neurophysiology recorder.
2. Motor evoked potentials: A magnetic coil is placed on the scalp at the anorectal
cortical site and discharged using magnetic energy. The anal and rectal motor evoked
potentials are then measured using a probe with 2 ring electrodes.
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