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NCT01235494 Clinical Trial

Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

Healthy Volunteers Clinical Trial

Official title:
Development of New MRI Pulse Sequences for Probing Lung Function in Volunteers With Hyperpolarised 3He Gas

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01235494
Other study ID # STH15080
Secondary ID
Status Completed
Phase Phase 1
First received
Last updated
Start date July 2010
Est. completion date December 31, 2020

Study information
Verified date December 2021
Source Sheffield Teaching Hospitals NHS Foundation Trust
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To develop techniques with MRI of Helium-3 gas to give functional images of the lungs. The goal is to test a single breath-hold functional 3-He MRI pulse sequence with sensitivity to multiple functional aspects of the luncg physiology. A group of 20 healthy volunteers willbe recruited from the local research group and the results compared with existing methods that require seperate breath-holds of 3He gas

Recruitment information / eligibility
Status Completed
Enrollment 36
Est. completion date December 31, 2020
Est. primary completion date December 31, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - age 18 -70 Exclusion Criteria: - contraindication to MRI - Resting oxygen saturation <95% - Volunteers requiring bronchodilators less than 4 hourly - additional respiratory diagnoses - pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• polarised 3 helium
1 inhalation (= 1 litre)

Locations
Country Name City State
United Kingdom Academic Unit of Radiology, Univeristy of Sheffield Sheffield South Yorkshire

Sponsors (2)
Lead Sponsor Collaborator
Sheffield Teaching Hospitals NHS Foundation Trust University of Sheffield

Country where clinical trial is conducted

United Kingdom, 

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