Healthy Volunteers Clinical Trial
Official title:
Damage to DNA Caused by UV-A Irradiation: Photochemical Mechanism and Cutaneous Parameters Involved in the Formation of Cyclobutane Pyrimidine Dimers
The DIMUVA study aims to evaluate the correlation between cutaneous phototype and the nature and quantity of damage caused to cutaneous DNA after exposure to UV-A radiation.
Due to their capacity to damage Deoxyribonucleic acid (DNA), Ultra-Violet (UV) radiation is
one of the causes of skin cancers.
Until recently, the genotoxic effects of UV-A radiation, were poorly identified, in
particular their capacity to lead to the dimerization of pyrimidine bases .
It is well known that the response to UV-A and UV-B radiations is different depending on the
cutaneous phototype.
Thus, the aim of this study is to determine the correlation between cutaneous phototype and
the quantity and nature (CPD or oxidative lesions) of damage caused to cutaneous DNA after
an ex-vivo exposure to UV-A and UV-B radiations.
;
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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