Healthy Volunteers Clinical Trial
Official title:
PET Imaging of Brain 5-HT1A Receptors Using [11C](-)-RWAY
This study will use positron emission tomography (PET) and magnetic resonance imaging (MRI)
to measure a serotonin receptor subtype in the brain called 5-HT(1A). This receptor is a
target for drug therapy to treat anxiety and depression. The study will see if a newly
developed radioligand (radioactive substance used in PET scanning to study the receptor
systems of the brain) called [(11)C](-)-RWAY is more effective than other radioligands
currently used in brain receptor research.
Healthy subjects 18-40 years of age may be eligible for this study. Candidates are screened
with a physical examination, electrocardiogram, and blood and urine tests.
Participants undergo PET and MRI scanning as follows:
PET scan
PET uses small amounts of a radioactive chemical called a tracer (in this case,
[(11)C](-)-RWAY) that "labels" active areas of the brain. For the procedure, the subject lies
on the scanner bed. A special mask is fitted to the subject's head and attached to the bed to
help keep the head still during the scan so the images will be clear. A brief scan is done
just before the tracer is injected to provide measures of the brain that will help in the
precise calculation of information from subsequent scans. Then, the tracer is injected
through a catheter (plastic tube) placed in the arm and pictures are taken for about 2 hours,
while the subject lies still on the scanner bed. Subjects return to the clinic for blood and
urine tests 24 hours after the scan.
MRI
The MRI scan is done within 1 year of the PET scan. MRI uses a magnetic field and radio waves
to produce images of body tissues and organs-in this case, the brain. The subject lies on a
table that is moved into the scanner (a tube-like device), wearing earplugs to muffle the
noise of the machine during the scanning process. The space in the scanner is confining and
may cause some people to be somewhat anxious. An intercom system allows the subject to speak
with the staff member performing the study at all times during the procedure, and the
procedure can be stopped at any time.
The 5-hydroxytryptamine (serotonin, 5-HT) 5-HT(1A) receptors subtype is a target for drug therapy in the treatment of anxiety and depression. Radioligands currently in use with PET for studying human brain 5-HT(1A) receptors in clinical research or drug development are based on WAY-100635. Though variously effective, they each suffer from one or more drawbacks with respect to measuring relative regional receptor densities. These drawbacks include: rapid metabolism and very low non-specific binding for [carbonyl-(11)C]WAY-100635; defluoridation for [18F]trans-FCWAY. Therefore, we have recently developed [(11)C](-)-RWAY as an alternative radioligand for brain 5 HT(1A) receptors. Even though similar to WAY-100635, [(11)C](-)-RWAY has a reversed amide linkage. Reversal of the direction of the amide bond may confer resistance to amide hydrolysis and make acceptable easy labeling at its O-methoxy group. In the present protocol, we plan to perform a kinetic brain imaging study in healthy human subjects to measure 5 HT(1A) receptors in brain regions with [(11)C](-)-RWAY. ;
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