Healthy Volunteers Clinical Trial
Official title:
The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography (MRA) Under Provocation With Glyceryl Trinitrate in Healthy Volunteers.
To examine the ability of MRA to measure the effect of GTN on the intra-cranial vascular response during the GTN-induced headache in healthy volunteers.
The only intra cranial structures innervated by sensory nerves, and therefore a possible
source of the headpain are the meninges and the large intracerebral arteries. The dilatation
of the cerebral vessels may not be the origin of the head pain per se, but measurements of
the intra cerebral vascular bed in the past has proven valuable in the migraine-research,
and has helped elucidate the basis for the migraine aura (Olesen, Friberg et al. 1990). The
effects of different signal molecules on the intra cerebral vasculature continue to be an
important field in the migraine research, in the search for possible pain causing signaling
molecules.
Therefore we have set up at study to examine if MR-Angiography (MRA) can be used for
monitoring of the vascular response after challenge with the known vasodilator GTN. This
drug was chosen because it is well characterized and a large body of evidence from earlier
studies could serve as background data (Thomsen 1997).
;
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic
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