Healthy Volunteers Clinical Trial
Official title:
Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans
Gut barrier plays a major role in defence of the organism. During catabolic states, like
major surgery or inflammation, gut barrier could be altered. It has been reported that
preoperative nutritional support may have beneficial effects on clinical outcome in patients
with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino,
have been reported to modulate inflammatory, antioxidant responses and protein metabolism in
intestine. In addition, glutamine supply improves clinical outcome in critically ill
patients. Antioxidant micronutrients may also have some beneficial effects in intestine by
improving antioxidant response and might also regulate protein expression. Nevertheless,
effects of glutamine combined to antioxidant micronutrients have not been evaluated.
Thus, the aim of this study will be to assess the influence of glutamine and
glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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