Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers

Healthy Volunteers Clinical Trial

Official title:

Etude de la Reserve Vasomotrice Microcirculatoire cutanée

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00152724
• Other study ID #: CP96-04
• Status: Completed
• Phase: N/A
• First received: September 8, 2005
• Last updated: October 30, 2017
• Start date: January 1996
• Est. completion date: November 2008

Study information

• Verified date: March 2007
• Source: University Hospital, Angers
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin. The purpose of the study is to investigate the physiological response of the cutaneous microcirculation to physical, thermal, mechanical or chemical stimulations.

Description:

This study has investigated various aspects of the physiology of the microcirculation in the past years and is still recruiting under parallel protocols of physiological investigations of the neurovascular control of the cutaneous microcirculation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 85
• Est. completion date: November 2008
• Est. primary completion date: November 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy volunteers with no clinical signs of, or risk factors for, vascular disease

Exclusion Criteria:

• Smokers, Pregnancy, Allergy,

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Device:
• pressure strain system, iontophoresis

Drug:
• scopolamin

• emla

• capsaicin

• aspirin

• clopidogrel

• celecoxib

• indomethacin

• acetylcholine

• sodium nitroprusside

• brethyllium

Device:
• general and local heating

Locations

Country	Name	City	State
France	Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers	Angers

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Angers

Country where clinical trial is conducted

France, 

References & Publications (7)

Durand S, Fromy B, Bouyé P, Saumet JL, Abraham P. Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms. J Physiol. 2002 Apr 1;540(Pt 1):261-9. — View Citation

Durand S, Fromy B, Humeau A, Sigaudo-Roussel D, Saumet JL, Abraham P. Break excitation alone does not explain the delay and amplitude of anodal current-induced vasodilatation in human skin. J Physiol. 2002 Jul 15;542(Pt 2):549-57. — View Citation

Durand S, Fromy B, Koïtka A, Tartas M, Saumet JL, Abraham P. Oral single high-dose aspirin results in a long-lived inhibition of anodal current-induced vasodilatation. Br J Pharmacol. 2002 Oct;137(3):384-90. — View Citation

Durand S, Fromy B, Tartas M, Jardel A, Saumet JL, Abraham P. Prolonged aspirin inhibition of anodal vasodilation is not due to the trafficking delay of neural mediators. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R155-61. — View Citation

Durand S, Tartas M, Bouyé P, Koïtka A, Saumet JL, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol. 2004 Dec 15;561(Pt 3):811-9. Epub 2004 Oct 21. — View Citation

Tartas M, Bouyé P, Koïtka A, Durand S, Gallois Y, Saumet JL, Abraham P. Early vasodilator response to anodal current application in human is not impaired by cyclooxygenase-2 blockade. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1668-73. Epub 2004 No — View Citation

Tartas M, Durand S, Koïtka A, Bouyé P, Saumet JL, Abraham P. Anodal current intensities above 40 microA interfere with current-induced axon-reflex vasodilatation in human skin. J Vasc Res. 2004 May-Jun;41(3):261-7. Epub 2004 May 19. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Amplitude of the vasomotor response to stimuli		1 hour
Secondary	Kinetics of the vasomotor response to stimuli		1 hour