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Healthy Volunteers clinical trials

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NCT ID: NCT03847987 Completed - Healthy Volunteers Clinical Trials

A 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation and the Effect of Food and Taste Assessment on the Tablet Formulation in Healthy Participants

Start date: March 12, 2019
Phase: Phase 1
Study type: Interventional

This is a two-part, open-label, healthy volunteer study. Part I will investigate the relative bioavailability of capsule and tablet formulations of RO7017773. Part II will explore how the taste of the tablet formulation is perceived with and without added sweetener/flavoring.

NCT ID: NCT03847610 Completed - Healthy Volunteers Clinical Trials

Minimally Invasive Sensing of Beta-lactam Antibiotics

MISBL
Start date: April 12, 2018
Phase: Phase 1
Study type: Interventional

This study is an in-house feasibility study of a microneedle biosensor developed within Imperial College London.

NCT ID: NCT03844906 Completed - Healthy Volunteer Clinical Trials

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Start date: December 27, 2018
Phase: Phase 1
Study type: Interventional

This study is a Phase 1, randomized, double-blind, placebo-controlled study of multiple doses of SAGE-718 using ketamine challenge to evaluate the electrophysiology, safety, tolerability, and pharmacokinetics in healthy subjects.

NCT ID: NCT03837093 Completed - Healthy Volunteers Clinical Trials

Low-dose IL-2 to the Kinetics of Regulatory T-cell in Healthy Volunteers

HEALTHIL-2
Start date: June 6, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and the dose-response relationship of ILT-101 to blood Tregs.

NCT ID: NCT03836859 Completed - Healthy Volunteers Clinical Trials

Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers

Start date: March 30, 2018
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to assess the safety and tolerability of a single short-term and a multiple dose scheme of rhNGF when administered as eye drops in healthy subjects of Japanese ethnicity. The secondary objective of this study is to assess the pharmacokinetics of single and multiple doses of rhNGF when administered as eye drops in healthy subjects of Japanese ethnicity.

NCT ID: NCT03835637 Completed - Healthy Volunteers Clinical Trials

Single and Multiple Dose Study of ORIC-101 in Adult Healthy Subjects

Start date: March 23, 2018
Phase: Phase 1
Study type: Interventional

This is a single centre, open-label, non-randomised study with up to 2 parts, assessing the safety, tolerability, PK and PD of single (Part A) and multiple (Part B; optional) doses of oral GR antagonist ORIC-101.

NCT ID: NCT03831503 Completed - Healthy Volunteers Clinical Trials

A Study of INO-A002 in Healthy Dengue Virus-naive Adults

Start date: February 7, 2019
Phase: Phase 1
Study type: Interventional

Phase 1, open label, single center, dose escalation study to evaluate the safety, tolerability and pharmacokinetic profile of dMAb-ZK190 following delivery of INO-A002 with Hylenex® recombinant delivered IM followed by EP in healthy adult Dengue naïve volunteers ages 18-60 years.

NCT ID: NCT03830112 Completed - Healthy Volunteers Clinical Trials

Effect of Two Pilates-based Mat Exercise Programs on the Isometric Strength of Core Muscles in Healthy Men

Start date: August 14, 2018
Phase: N/A
Study type: Interventional

Based on the current evidence, it is known that Pilates is an exercise technique that has been used mainly by women in sport, fitness and rehabilitation. Most research has been developed with women. The participation of men in the research studies is reduced and methodology rigor is low, therefore, there is insufficient evidence on the effects of this type of training in men, in addition, there are no studies that have proven the effects of a Pilates-based mat exercise with resistance band on strength of core muscles. The main objective of this research is to identify the effects of a Pilates-based mat exercise program versus a Pilates-based exercise mat program with resistance band on the isometric strength of the core muscles in men 18 to 25 years.

NCT ID: NCT03827642 Completed - Healthy Volunteer Clinical Trials

A Study to Compare Bioavailability of Naloxone Nasal Spray, Naloxone Hydrochloride (HCl) Intravenous (IV) and Intramuscular Injection (IM) in Healthy Volunteers

Start date: April 23, 2018
Phase: Phase 1
Study type: Interventional

The main objective of this study was to compare the bioavailability of two test formulations of Naloxone Nasal Spray with the reference formulations of Naloxone HCl IV and IM injection under fasted conditions.

NCT ID: NCT03827629 Completed - Healthy Volunteer Clinical Trials

A Study to Compare Bioavailability of Naloxone Nasal Spray and Naloxone Hydrochloride (HCl) Intramuscular Injection (IM) in Healthy Volunteers

Start date: August 7, 2017
Phase: Phase 1
Study type: Interventional

The main objective of this study is to compare early exposures of two test formulations of Naloxone Nasal Spray with the reference formulation of Naloxone HCl IM Injection under fasted conditions.