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Healthy Volunteers clinical trials

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NCT ID: NCT01702649 Completed - Healthy Volunteers Clinical Trials

Safety, Tolerability, Pharmacokinetics of Intravenous RPX2003 (Biapenem) in Healthy Adult Subjects

Start date: August 2012
Phase: Phase 1
Study type: Interventional

RPX2003 (biapenem) is being studied in combination with a beta-lactamase inhibitor to treat bacterial infections, including those due to multi-drug resistant bacteria.

NCT ID: NCT01702506 Completed - Healthy Volunteers Clinical Trials

Evaluation Of The Potential Effect That The Administration Of Food Or Antacid Medication May Have In The Oral Absorption Of Dacomitinib (PF-00299804)

Start date: October 2012
Phase: Phase 1
Study type: Interventional

Evaluation of the potential effect that the administration of food or antacid medication may have in the oral absorption of dacomitinib relative to the administration of dacomitinib in absence of food or antacid medication

NCT ID: NCT01701739 Completed - Healthy Volunteer Clinical Trials

A Pharmacokinetics Study of Aleglitazar in Combination With Digoxin in Healthy Volunteers

Start date: October 2012
Phase: Phase 1
Study type: Interventional

This open-label, two-period, fixed-sequence study will investigate the pharmacokinetics and safety of multiple doses of aleglitazar on a single dose of digoxin in healthy volunteers. In period 1, volunteers will receive a single dose of digoxin, in period 2 volunteers will receive multiple doses of aleglitazar and a single dose of digoxin. The anticipated time on study treatment is one month.

NCT ID: NCT01701089 Completed - Clinical trials for Healthy Volunteer, Alzheimer's Disease

A Study of RO4602522 in Patients With Alzheimer Disease and in Healthy Volunteers

Start date: September 2012
Phase: Phase 1
Study type: Interventional

This open-label, multiple dose, parallel group study will assess the monoamine oxidase in the brain by in vivo positron emission tomography (PET) and safety of RO4602522 in patients with Alzheimer disease and in healthy volunteers. Patients and volunteers will receive multiple doses of RO4602522 and up to three injections of C11-L-deprenyl-D2 used in the PET.

NCT ID: NCT01697436 Completed - Healthy Volunteer Clinical Trials

A Bioequivalence Study of an Oral Solution of Copegus (Ribavirin) Compared to Copegus Tablets

Start date: September 2012
Phase: Phase 1
Study type: Interventional

This four-period, single-center, open-label, single-dose, randomized, cross-over study will assess the bioequivalence and safety of an oral solution of Copegus (ribavirin) compared to a Copegus tablet in healthy adult volunteers. Volunteers will be randomized to one of four sequences in which they will receive the treatment under fed and under fasted conditions.

NCT ID: NCT01689636 Completed - Healthy Volunteers Clinical Trials

Safety and Biodistribution of Technetium Tc 99m EC20 in Normal Volunteers and Ovarian Cancer Patients

Start date: August 2000
Phase: Phase 1
Study type: Interventional

Open-label, single-center, single-treatment group, baseline-controlled (for safety) study of the safety and biodistribution of Technetium Tc 99m EC20 in four normal subjects and four subjects with known or suspected ovarian cancer.

NCT ID: NCT01689116 Completed - Healthy Volunteers Clinical Trials

Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers

Start date: August 31, 2012
Phase: Phase 1
Study type: Interventional

This is a single-center, multiple-dose, randomized, double-blind, double-dummy, placebo-controlled, active-comparator, parallel study in healthy volunteers.

NCT ID: NCT01689038 Completed - Healthy Volunteers Clinical Trials

Brain Imaging Study of F17464

Start date: November 2012
Phase: Phase 1
Study type: Interventional

Assess the binding rate of F17464 to cerebral receptors in healthy volunteers.

NCT ID: NCT01686217 Completed - Healthy Volunteers Clinical Trials

A Phase I Study to Compare 3 Different Strengths of an Extended Release Formulation of ASP015K to an Immediate Release Formulation of ASP015K

Start date: June 2012
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the pharmacokinetics (PK) profiles of three different strengths of ASP015K extended release formulation and an immediate release formulation and to evaluate food effect on extended release strengths in healthy volunteers.

NCT ID: NCT01684891 Completed - Healthy Volunteer Clinical Trials

A 28-Day Pharmacokinetics Study of RG1662 in Healthy Male Volunteers

Start date: September 2012
Phase: Phase 1
Study type: Interventional

This is a single-center, open label, multiple dose study to investigate the pharmacokinetics of RG1662 given twice daily over 28 days, and in addition, the excretion and metabolism of [13C]-labeled IV microdoses and an oral [14C]-labeled dose of RG1662 in healthy male volunteers. The anticipated time of study treatment is 4 weeks.