Healthy Subjects Clinical Trial
Official title:
Konditionerende Smertestimuli - Sammenligning af Forskellige Test og Konditioneringsmodaliteter
An extensive amount of studies indicate that conditioned pain modulation (CPM) test
paradigms can be of use to evaluate the efficacy of the endogenous pain inhibition pathway
in healthy controls and pain patients. A number of studies indicate that the autonomic
nervous system (ANS) responds to painful stimulation by parasympathetic activity withdrawal
and up-regulation of sympathetic activity (flight-or-fight mode), but it remains unknown
whether these responses predict individual pain susceptibility or CPM efficacy and whether
different pain modalities evoke different physiological stress responses, i.e. do
individuals with low pain tolerance exhibit more vigorous ANS responses when subjected to
controlled acute pain stimuli, and do high ANS responsiveness to pain coincide with altered
psychophysical pain levels/CPM efficacy.
This study aims to investigate the effect of ANS responsiveness on CPM paradigms and to
investigate if an exogenous, pharmaceutically induced decrease in the sympathetic drive of
the ANS will yield decreased CPM efficacy.
n/a
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