Study of the Neural Basis of Analogical Reasoning

Healthy Subjects Clinical Trial

— ANALOG  

Official title:

Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02236832
• Other study ID #: C14-17'
• Secondary ID: 140662B-312014-A
• Status: Completed
• Phase: N/A
• Start date: February 2015
• Est. completion date: February 2021

Study information

• Verified date: March 2017
• Source: Institut National de la Santé Et de la Recherche Médicale, France
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 130
• Est. completion date: February 2021
• Est. primary completion date: February 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 85 Years

Eligibility

Inclusion Criteria:

Healthy subjects:

• subject affiliated to national health insurance
• informed consent signed
• normal neurological examination
• subject aged at least 20

Patients:

• FTD or PSP diagnostic criteria filled
• patient affiliated to national health insurance
• informed consent signed

Exclusion Criteria:

• Severe psychiatric symptomatology and psychotropic drug use
• unability to understand or perform the cognitive tasks.

Related Conditions & MeSH terms

• Aphasia, Primary Progressive
• Frontotemporal Dementia
• Healthy Subjects
• Pick Disease of the Brain
• Progressive Supranuclear Palsy
• Supranuclear Palsy, Progressive

Intervention

Device:
• transcranial magnetic stimulation

Other:
• MRI imaging

• EEG recording

Behavioral:
• Neuropsychological examination

Locations

Country	Name	City	State
France	ICM (Institut du cerveau et de la Moelle épinière)	Paris

Sponsors (2)

Lead Sponsor	Collaborator
Institut National de la Santé Et de la Recherche Médicale, France	Fondation pour la Recherche Médicale

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Performance in the implicat task	Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60).; Participants will come only once during one day ot the research centre.	day of inclusion (one day)
Primary	Performance in the Similitude task	Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40).; Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.	from inclusion to 4 months after inclusion
Secondary	recording of EEG	EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials.; Participants will come only once during one day a the research centre.	day of inclusion (one day)
Secondary	Analysis of MRI	T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.; Participants will come only once during one day at the research centre	day of inclusion (one day)