Effects of Brain Stimulation During Nocturnal Sleep on Memory Consolidation in Younger, Healthy Subjects

Healthy Subjects Clinical Trial

Official title:

Impact of Transcranial Slow Oscillating Stimulation on Memory Consolidation During Nocturnal Slow Wave Sleep in Younger, Healthy Subjects

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01832740
• Other study ID #: Nighttime sleep-tSOS-Young
• Status: Completed
• Phase: N/A
• First received: March 8, 2013
• Last updated: March 15, 2016
• Start date: January 2013
• Est. completion date: January 2015

Study information

• Verified date: March 2016
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Health authority: Germany: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The beneficial effect of nocturnal sleep on memory consolidation is well-documented in young, healthy subjects. Especially, periods rich in slow-wave sleep (SWS) have shown a memory enhancing effect on hippocampus-dependent declarative memory. Slow oscillatory activity typically occuring during SWS has been implicated in the consolidation effect. In this study we investigate if the consolidation effect can be amplified by the application of a weak transcranial oscillatory electric current within the frequency range of SWS in humans (0,7-0,8 Hz) during nocturnal SWS.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: January 2015
• Est. primary completion date: January 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• healthy Subjects

• unobtrusive, neuropsychological screening

• age: 18-35 years

• right handed

Exclusion Criteria:

• untreated severe internal or psychiatric diseases

• epilepsy

• other severe neurological diseases eg., previous major stroke, brain tumour

• contraindications to MRI

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy Subjects

Intervention

Device:
• brain stimulation
oscillating direct current brain stimulation
• SHAM
no stimulation

Locations

Country	Name	City	State
Germany	Charite CCM Neurologie Berlin	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

References & Publications (2)

Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010 Feb;11(2):114-26. doi: 10.1038/nrn2762. Epub 2010 Jan 4. Review. — View Citation

Marshall L, Helgadóttir H, Mölle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006 Nov 30;444(7119):610-3. Epub 2006 Nov 5. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Retention of declarative memories after 0.75 Hz stimulation during SWS, vs after sham stimulation during SWS	Retention (difference values between performance at retrieval after sleep minus performance at learning before sleep) between stimulation conditions (0.75 Hz during SWS, vs sham stimulation during SWS) in the declarative memory task.	4 weeks	No
Secondary	1. Amount of Slow wave Sleep	1. Amount of slow wave sleep assessed by standard polysomnographic criteria in 0,75 Hz vs SHAM stimulation during SWS.	4 weeks	No
Secondary	2. sleep spindels	2. Spindel activity during sleep indicated via several spindel parameters like number, duration, frequency of spindles; compared between 0,75 Hz and SHAM stimulation during SWS.	4 weeks	No
Secondary	3. EEG-correlates	3. Neuronal correlates (EEG-power in slow oscillation frequency bands induced by 0,75 Hz vs SHAM stimulation during SWS; EEG-correlates of encoding and retrieval of a declarative memory task).	4 weeks	No
Secondary	4. further memory systems	4. Performance in further memory systems (procedural), compared between 0,75 Hz and SHAM stimulation during SWS.	4 weeks	No