Healthy Subjects Clinical Trial
Official title:
A Study to Characterize the Durability of Hypertonic Saline for the Enhancement of Mucociliary Clearance in Healthy Subjects
The purpose of this research study is to learn about how long hypertonic saline (HS) works
in healthy subjects. Inhaled hypertonic saline is one of the medications used to treat
Cystic Fibrosis (CF). In CF and more common lung diseases like chronic bronchitis, mucus
builds up in the lungs. Hypertonic saline and other medications currently being developed
may help patients with these lung diseases by speeding up mucus clearance from the lung. For
these treatments to be effective, they likely need to be able to act for at lease several
hours. Investigators are able to measure how lung treatments like hypertonic saline work by
conducting a Mucociliary Clearance (MCC) scan. Currently, the investigators do not know how
long hypertonic saline works in people who do not have CF. Investigators plan to use this
information to improve the design and testing of new treatments for patients with chronic
bronchitis.
Objectives:
1. The investigators will use MCC measurements to determine the durability of action of
hypertonic saline in healthy (i.e. non-CF) subjects.
2. The investigators will determine the intra- and inter-individual variability of
baseline MCC measurements using a slow inhalation/large particle protocol in healthy
subjects to guide future sample size calculations.
n/a
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