Healthy Subjects Clinical Trial
Official title:
Clinical Assessment of Negative Symptoms Neurocognitive and Electrophysiological Characteristics in Chronic Cannabis Users
The aim of the current study is set out to find a human model for negative symptoms based on
clinical observation that chronic cannabis users express negative symptoms and characterize
by the same neurocognitive and electrophysiology characteristics like patient suffer from
schizophrenia. Towards that end the first part of the study is set out to explore weather
chronic cannabis user's express negative symptoms similar to patient suffer from
schizophrenia. The second part of the study will explore the neurocognitive and
electrophysiology characteristics of those cannabis users that express negative symptoms.
This data will be compared to parallel data of schizophrenia patients with predominantly
negative symptom.
Several lines of biological and genetic evidence support the cannabinoid hypothesis for
schizophrenia. Particularly, it is most significant clinically that the possible involvement
of the cannabinoid system in the neural basis for the negative symptoms. This hypothesis
based on clinical findings that chronic cannabis use causes a combination of symptoms
including apathy, avolition, lack of interest, passivity, and cognitive impairments, the
so-called "amotivational syndrome," which resembles the core negative symptoms of
schizophrenia in behavioral level as well as the brain level. Both are associated with the
functions or integrity of the frontal lobe due to its role in creating self-directed
behaviors, deficits in which may underlie alogia, anhedonia, and flat affect. Despite the
aforementioned similarities, to date, there is no documentation for such a relationship.
Recognition that chronic cannabis users share the same or similar constellation of symptoms
and similar neurocognitive and electrophysiology characteristics could provide a key to
develop a human model for negative symptoms and an essential tool to comprehensive
understanding of the etiology of negative symptoms and development of an innovative therapy.
The investigators Hypothesize That Chronic Cannabis Users Would Express the Same
Constellation of Behaviors as Negative Symptoms of Schizophrenia; as well as similar
neurocognitive and electrophysiology characteristics
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05483998 -
A Study to Evaluate Single and Multiple Doses of TLC-2716 in Healthy Participants
|
Phase 1 | |
| Recruiting |
NCT02235012 -
Cognitive Biases Under Ketamine
|
N/A | |
| Recruiting |
NCT02417714 -
Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)
|
||
| Completed |
NCT05088343 -
Effect of Hetrombopag on the Pharmacokinetics of Rosuvastatin in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04418973 -
Analysis of Breath Volatile Organic Compounds After Dyspnea Induced in the Healthy Subject.
|
N/A | |
| Not yet recruiting |
NCT06248801 -
Vildagliptin and Metformin Tablets 50/1000 mg Relative to GALVUS MET (50mg/1000 mg) Tablets
|
Phase 1 | |
| Terminated |
NCT04068259 -
Single Ascending Dose Study of PBI-4547 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT03279302 -
Trial to Evaluate the PK Profile of Glepaglutide (ZP1848) After a Single IV and After Multiple SC Injections in Healthy Subjects
|
Phase 1 | |
| Not yet recruiting |
NCT06233162 -
Febuxostat 80 mg Tablets Relative to Feburic® 80 mg Tablets
|
Phase 1 | |
| Recruiting |
NCT04159844 -
Evaluation of the Stiffness and Pressure Applied on the Lower Leg by a New Compression Bandage on Healthy Subjects
|
N/A | |
| Completed |
NCT06137911 -
Evaluation of Safety, Tolerability & Pharmacokinetics of JYP0061 in Healthy Adults.
|
Phase 1 | |
| Completed |
NCT04849286 -
Measurement of HTL0016878 in Cerebrospinal Fluid
|
Phase 1 | |
| Not yet recruiting |
NCT06233227 -
Dutasteride Soft Capsule 0.5 mg Relative to Avodart 0.5 mg Soft Capsule
|
Phase 1 | |
| Completed |
NCT04096157 -
A Study to Assess Isavuconazole Following a Single Dose of Isavuconazonium Sulfate Intravenous Solution Via Nasogastric (NG) Tube Compared to a Single Dose of Oral Capsules Under Fasting Conditions in Healthy Participants
|
Phase 1 | |
| Completed |
NCT01200368 -
Trial Evaluating a 13-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants
|
Phase 3 | |
| Recruiting |
NCT05805033 -
Peri-Implant Soft Tissue Integration in Humans: Influence of Material
|
N/A | |
| Completed |
NCT04027803 -
Comparative Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Single Intravenous Doses of BCD-148 and Soliris®
|
Phase 1 | |
| Recruiting |
NCT03467880 -
Multicenter Study of Impulse Oscillometry in Chinese
|
N/A | |
| Completed |
NCT02903095 -
Single Ascending Dose Study of TD-1439 in Healthy Subjects
|
Phase 1 | |
| Active, not recruiting |
NCT02341508 -
A Phase 1a, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate Lpathomab in Healthy Volunteers
|
Phase 1 |