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NCT00999271 Clinical Trial

Glucose-dependent Insulinotropic Polypeptide (GIP) and Lipid Metabolism

Healthy Subjects Clinical Trial

Official title:
On the Role of Glucose-dependent Insulinotropic Polypeptide, GIP, in Postprandial Metabolism in Humans

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00999271
Other study ID # HD-2009-0025
Secondary ID
Status Completed
Phase N/A
First received October 20, 2009
Last updated October 20, 2009
Start date August 2008
Est. completion date September 2009

Study information
Verified date October 2009
Source Hvidovre University Hospital
Contact n/a
Is FDA regulated No
Health authority Denmark: The Danish National Committee on Biomedical Research Ethics
Study type Observational

Clinical Trial Summary

The aim of this proposal is to examine whether endogenous GIP and exogenous GIP alone and in combination with insulin affect gastric emptying (GE), appetite, energy intake, energy expenditure (EE) and plasma levels of triglycerides (TAG), free fatty acids FFA) and glycerol in man.

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date September 2009
Est. primary completion date September 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:

- Informed oral and written consent

- Caucasians over the age of 18 years

- Normal 75 g oral glucose tolerance test (OGTT)

- Normal blood haemoglobin concentration

- Normal plasma lipid profile

Exclusion Criteria:

- First-degree relatives with diabetes and familial hypertriglyceridemia

Study Design

Observational Model: Case Control

Related Conditions & MeSH terms

Intervention

Other:
• Incretin hormone - Glucose-dependent insulinotropic polypeptide (GIP)
two different dosages: 0.8 pmol/kg/min 1.5 pmol/kg/min for 300 minutes

Locations
Country Name City State
Denmark Hvidovre Hospital Hvidovre

Sponsors (1)
Lead Sponsor Collaborator
Hvidovre University Hospital

Country where clinical trial is conducted

Denmark, 

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