Healthy Subjects Clinical Trial
Official title:
Pharmacokinetics of Ghrelin in Normal Subjects
The main purpose of this study is to determine the half life of the hormone "ghrelin" in the human body. Other purposes are to investigate the effect of ghrelin on appetite and cardiovascular function.
Ghrelin is a recently described acylated peptide hormone produced by the enteroendocrine
cells of the mucosal epithelial layer in the ventricle. Ghrelin is the endogenous ligand for
the growth hormone (GH) secretagogue receptor (GHS-R).
Ghrelin stimulates pituitary GH release by binding to the GHS-R at both hypothalamic and
pituitary levels.
Several studies show that bolus injections of ghrelin have positive effects on cardiac
function in healthy humans as well as in humans with cardiac disease. We investigate the
changes in cardiac function during ghrelin infusion in healthy subjects.
The pharmacokinetics of ghrelin is described in few studies only, and we aim to elucidate
this aspect further.
Comparisons: In a double blind, placebo controlled, cross over study we investigate the
effect of 180 minutes ghrelin infusion on 1. cardiac function (tissue Doppler,
stroke-velocity index), 2. vascular tone (a. brachialis dilatation), 3. ghrelin-half-life
(acylated and des-acylated) and other pharmacokinetic parameters and 4. effect on appetite.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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