Role of the Posterior Parietal Cortex in the Processing of Sensory Information

Healthy Subject Clinical Trial

— CORTEX  

Official title:

Role of the Posterior Parietal Cortex in the Processing of Sensory Information Modulating the Excitability of the Primary Motor Cortex in Humans

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03386188
• Other study ID #: 2014_32
• Secondary ID: 2014-A01507-40
• Status: Recruiting
• Phase: N/A
• Start date: January 2016
• Est. completion date: July 18, 2021

Study information

• Verified date: August 2020
• Source: University Hospital, Lille
• Contact: Philippe Derambure, MD,PhD
• Email: philippe.derambure[@]chru-lille.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: July 18, 2021
• Est. primary completion date: January 18, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Right handed

• No neurological troubles

• Informed consent signed

• Affiliated to a social security

Exclusion Criteria:

• Psychiatric antecedent

• Neurological disease

• Contra-indication to TMS

• Under psychiatric treatment

• Pregnancy

• Contra-indication to MRI

Related Conditions & MeSH terms

• Healthy Subject

Intervention

Device:
• Transcranial Magnetic Stimulation (TMS)
Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.
• Electrical Muscle Activity (EMG)
Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Locations

Country	Name	City	State
France	Hôpital Roger Salengro, CHRU de Lille	Lille

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Afferent induced facilitation	Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms	Baseline
Secondary	Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI)	Effect of median nerve stimulation on LICI at 100ms interval	Baseline