Healthy Participants Clinical Trial
Official title:
Functional Roles of Dorsolateral Prefrontal Cortex in Visuomotor Adaptation and Response Selection
Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in cognitive functions such as executive function, response selection, and working memory. By applying transcranial magnetic stimulation (TMS) or transcranial focused ultrasound (FUS), which is a technology to temporally alter brain state in the stimulation site, the investigators aim to find supporting evidence for the causal relationship between the targeted stimulation site and motor learning improvement or response selection.
The purpose of this study is to test the functions of dorsolateral prefrontal cortex in human
motor learning. Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in
cognitive functions such as executive function, response selection, and working memory.
Recent Findings hint potential involvement of dorsolateral prefrontal cortex in motor
learning. Rare studies provided supporting evidence on its involvement and functions. This
study aims to examine the functional roles of dorsolateral prefrontal cortex in human motor
learning. By applying transcranial magnetic stimulation (TMS) or transcranial focused
ultrasound (FUS), which is a technology to temporally alter brain state in the stimulation
site, the investigators aim to find supporting evidence for the causal relationship between
the targeted stimulation site and motor learning improvement or response selection.
Young healthy adults will be recruited and randomly assigned to one of four experimental
groups. If randomized into one of the TMS groups, participants will learn to adapt to two
visual rotations (20 and 60 degrees) when reaching for a virtual target, subjects will
receive repetitive TMS (rTMS) stimulation over the targeted location, left DLPFC, or right
DLPFC depending on the study group. How rTMS stimulation influencing the acquisition and
retention of motor memory will be assessed based on group comparison of behavioral measures
such as reaching accuracy. If randomized into the FUS group, participants will complete a
flanker task to focuses on the assessment of response selection and inhibitory control.
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