Healthy Men Clinical Trial
Official title:
Application of the Indicator Amino Acid Oxidation Technique for the Determination of Metabolic Availability of Lysine From Sorghum Protein, in Young Adult Men
Verified date | April 2019 |
Source | The Hospital for Sick Children |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Protein is the key determinant of growth and bodily functions. The quality of food proteins
depend on their amino acid content and the amount of amino acids used by the body to make
proteins. Globally Cereal Grains (CG) provide 50% of the calories and protein in the diet and
exceed 80% in poorer developing countries. In many of those countries, sorghum is the major
cereal grain in the diet. The protein in sorghum is low in the essential amino acid lysine.
Hence sorghum protein is of low quality. Low lysine affects protein synthesis in the body.
Cooking methods also affect the lysine available from foods to the body.The protein can be
complemented by the addition of lentils to augment the low lysine content. However, lentils
are prohibitively expensive in some developing countries.
As the human population increases, the world faces the continuous challenge of maximizing a
limited food supply. Protein quality (PQ) evaluation of sorghum directly in humans would
allow us to bridge the gap in knowledge between what is required and how best to provide.The
information gathered from this project will provide the first direct experimental data on PQ
of sorghum protein in humans on which nutrition recommendations can be built.
Status | Completed |
Enrollment | 7 |
Est. completion date | November 22, 2018 |
Est. primary completion date | September 1, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 49 Years |
Eligibility |
Inclusion Criteria: - Male, age 18 - 49 yrs Healthy, with no known clinical condition which would affect protein or AA metabolism, ex. Diabetes Stable Body Weight Not on any medications that could affect protein or amino acid metabolism e.g. steroids Exclusion Criteria: - Unwillingness to participate or unable to tolerate the diet Recent history of weight loss within the last 3 months or on a weight reducing diet Inability to tolerate study diets (ex. Allergy to ingredients) |
Country | Name | City | State |
---|---|---|---|
Canada | The Hospital for Sick Children | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
The Hospital for Sick Children | Canadian Institutes of Health Research (CIHR) |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of the protein quality of Sorghum by determining the Metabolic availability of Lysine. | The MA of lysine in sorghum will be studied using the IAAO technique with L-(1-13C) phenylalanine as the indicator. In order to determine the MA of lysine, four levels of lysine will be tested; (5, 8, 12, 15 mg/kg/d which represent 13, 21, 32 and 40% of the lysine requirement for adults (37 mg/kg/d)) in five healthy adult men in a repeated measures design. Each subject will participate in 8 experiments: 4 lysine intakes as L-lysine from crystalline amino acid, 3 intakes of lysine from sorghum prepared by moist cooking and 1 experiment for dietary complementation with lentils. The MA of lysine will be estimated by comparing the IAAO response to varying intakes of Lysine in cooked sorghum compared with the IAAO response to lysine intakes in the reference protein (crystalline amino acid mixture patterned after egg protein) using the slope ratio method. | 2 years |
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