Healthy Men Clinical Trial
Official title:
Application of the Indicator Amino Acid Oxidation Technique for the Determination of Metabolic Availability of Lysine From Millet Protein, in Young Adult Men
Verified date | April 2019 |
Source | The Hospital for Sick Children |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Protein is the key determinant of growth and bodily functions. The quality of food proteins
depend on their amino acid content and the amount of amino acids used by the body to make
proteins. Globally Cereal Grains (CG) provide 50% of the calories and protein in the diet and
exceed 80% in poorer developing countries. In many of those countries, millet is the major
cereal grain in the diet. The protein in millet is low in the essential amino acid lysine.
Hence millet protein is of low quality. Low lysine affects protein synthesis in the body.
Cooking methods also affect the lysine available from foods to the body.The protein can be
complemented by the addition of lentils to augment the low lysine content. However, lentils
are prohibitively expensive in some developing countries.
As the human population increases, the world faces the continuous challenge of maximizing a
limited food supply. Protein quality (PQ) evaluation of millet directly in humans would allow
us to bridge the gap in knowledge between what is required and how best to provide.The
information gathered from this project will provide the first direct experimental data on PQ
of millet protein in humans on which nutrition recommendations can be built.
Status | Completed |
Enrollment | 5 |
Est. completion date | January 31, 2019 |
Est. primary completion date | January 31, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 49 Years |
Eligibility |
Inclusion Criteria: - Male, age 18 - 49 yrs Healthy, with no known clinical condition which would affect protein or AA metabolism, ex. Diabetes Stable Body Weight Not on any medications that could affect protein or amino acid metabolism e.g. steroids Exclusion Criteria: - Unwillingness to participate or unable to tolerate the diet Recent history of weight loss within the last 3 months or on a weight reducing diet Inability to tolerate study diets (ex. Allergy to ingredients) |
Country | Name | City | State |
---|---|---|---|
Canada | The Hospital for Sick Children | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
The Hospital for Sick Children | Canadian Institutes of Health Research (CIHR) |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Metabolic availability of Lysine in millet | Apply the IAAO method to determine the Metabolic availability of Lysine in millet prepared by wet heat cooking method. | 2 years |
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