Healthy Men Clinical Trial
Official title:
Investigation on Acute Dose-Dependent Effects of Anthocyanins on Endothelial Function
Verified date | November 2017 |
Source | Heinrich-Heine University, Duesseldorf |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Anthocyanins are a subclass of (poly)phenols very abundant in berries and red grapes. Increasing evidence from human epidemiological and dietary intervention studies suggests that anthocyanins may have cardiovascular health benefits. The present study aimes to investigate whether pure anthocyanin consumption improves endothelial function in healthy individuals and if these effects are dose-dependent.
Status | Completed |
Enrollment | 10 |
Est. completion date | October 31, 2017 |
Est. primary completion date | August 8, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 45 Years |
Eligibility |
Inclusion Criteria: - Healthy men aged 18-45 years old - Subjects are willing to maintain their normal eating/drinking habits and exercise habits to avoid changes in body weight over the duration of the study - subjects are able to understand the nature of the study - able to give signed written informed consent - signed written infomred consent form - healthy male subjects (no clinical signs or symptoms of CVD. Exclusion Criteria: - cardiovascular disease, acute inflammation, cardiac arrhythmia, renal failure, heart failure (NYHA II-IV), diabetes mellitus, C-reactive protein > 0.5 mg/dL, malignant disease, hypotension (=100 / 60 mm Hg) |
Country | Name | City | State |
---|---|---|---|
Germany | Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital Duesseldorf | Duesseldorf |
Lead Sponsor | Collaborator |
---|---|
Heinrich-Heine University, Duesseldorf |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Other Pre-specified Outcome Measures | Plasma (poly)phenol metabolites measured by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF MS) | 0 and 2 hours postconsumption | |
Primary | Endothelial function | Flow-mediated dilation | Changes from baseline to 2 hours postconsumption | |
Secondary | Blood pressure | Automatic measurements | 0 and 2 hours postconsumption |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02575209 -
Gender Differences in Social Cognition in Patients With Schizophrenia of Recent Diagnosis and Healthy Controls Subjects
|
N/A | |
Completed |
NCT00900107 -
Time-Dependent Mobilization of Circulating Progenitor Cells During Strenuous Exercise in Healthy Individuals
|
N/A | |
Completed |
NCT02517775 -
Effects of Cranberry Consumption in Vascular Function in Healthy Individuals
|
N/A | |
Active, not recruiting |
NCT03298373 -
28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men
|
Phase 1 | |
Completed |
NCT03339167 -
Metabolic Availability of Lysine From Millet in Adult Men
|
N/A | |
Completed |
NCT01710280 -
Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia
|
N/A | |
Completed |
NCT01130948 -
Sleep, Breathing and Psychomotor Performance at Altitude: A Physiologic Study in Healthy Subjects
|
N/A | |
Completed |
NCT01382069 -
Phase 1 Study of Dimethandrolone Undecanoate in Healthy Men
|
Phase 1 | |
Recruiting |
NCT05523674 -
Effects of Warm-up Intensity and Blood Flow Restriction
|
N/A | |
Not yet recruiting |
NCT05865574 -
A Comparative Pharmacokinetic Study to Evaluate Different Manufacturing Batches of BAT1706 Injection
|
Phase 1 | |
Completed |
NCT01293591 -
Garlic Intake And Biomarkers Of Cancer Risk
|
N/A | |
Completed |
NCT01296997 -
Calcium Phosphate and Incretins
|
N/A | |
Completed |
NCT00935662 -
A First Time in Man, Study to Assess the Safety of AZD8329 After Single Ascending Oral Doses
|
Phase 1 | |
Completed |
NCT01221558 -
Effects of Lycopene on Oxidative Stress and Markers of Endothelial Function Healthy Men
|
Phase 3 | |
Active, not recruiting |
NCT05825781 -
Study, Evaluating Pharmacokinetics, Immunogenicity and Safety Profiles of Pertuzumab Compared to Perjeta® in Healthy Man
|
Phase 1 | |
Completed |
NCT02994602 -
Study of Serum Testosterone and Nestorone in Females After Secondary Exposure to Nestorone ® (NES) + Testosterone (T) Combined Gel Applied to Shoulders and Upper Arms in Males
|
Phase 1 | |
Completed |
NCT02365987 -
The Acute Effects of Interesterification of Commercially Used Fats on Postprandial Lipaemia and Satiety
|
N/A | |
Completed |
NCT02093169 -
D2 Dopamine Receptor Occupancy After Oral Dosing of Lu AF35700 in Healthy Men Using [11C]-PHNO as Tracer Compound
|
Phase 1 | |
Completed |
NCT02072278 -
Electroencephalography Study Investigating the Effects of Vortioxetine in Healthy Male Subjects
|
Phase 1 | |
Completed |
NCT03411005 -
Metabolic Availability of Lysine From Sorghum in Adult Men
|
N/A |