Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Healthy Men Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01710280
• Other study ID #: IRIS
• Status: Completed
• Phase: N/A
• Start date: May 2011
• Est. completion date: June 2012

Study information

• Verified date: September 2019
• Source: King's College London
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: June 2012
• Est. primary completion date: December 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• Healthy males

• Non-smokers

• Aged 40-70 years

• Fasting TAG concentrations =1.5 mmol/L.

Exclusion Criteria:

• Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose = 6.1 mmol/L), cancer, kidney, liver or bowel disease.

• Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.

• History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men)

• Current self-reported weekly alcohol intake exceeding 28 units

• Allergy or intolerance to any component of test meals

• Unwilling to restrict consumption of any source of fish oil for the length of the study

• Weight change of >3kg in preceding 2 months

• Body Mass Index <20 and >35 kg/m2

• Fasting blood cholesterol > 7.8 mmol/L

• Current cigarette smoker.

• Current use of lipid lowering medication

Related Conditions & MeSH terms

• Healthy Men
• Raised Fasting Plasma Triacylglycerol Concentrations

Intervention

Dietary Supplement:
• High-fat meal containing native palm olein

• High-fat meal containing interesterified palm olein

Locations

Country	Name	City	State
United Kingdom	Diabetes & Nutritional Sciences Division, King's College London.	London

Sponsors (1)

Lead Sponsor	Collaborator
King's College London

Country where clinical trial is conducted

United Kingdom, 

References & Publications (1)

Sanders TA, Filippou A, Berry SE, Baumgartner S, Mensink RP. Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism. Am J Clin Nutr. 2011 Dec;94(6):1433-41. doi: 10.3945/ajcn.111.017459. Epub 2011 Oct 26. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Incremental AUC for plasma total cholesterol concentrations		1-6 h post-meal
Primary	Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations		1-6 h post-meal
Secondary	Incremental AUC for plasma non-esterified fatty acid concentrations		1-6 h post-meal
Secondary	Changes from baseline in digital volume pulse		2,4,5,6 h post-meal
Secondary	Changes from baseline in blood pressure		2,4,5,6 h post-meal

External Links

•   Primary publication