Metabolic Dynamics During Physical Activity

Healthy Men and Women Clinical Trial

Official title:

Metabolic Dynamics During Physical Activity Under Normobaric Normoxia or Moderate Hypoxia - a Pilot Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03485716
• Other study ID #: Hypoxitrain 2
• Status: Completed
• Phase: N/A
• First received: March 19, 2018
• Last updated: March 30, 2018
• Start date: August 1, 2016
• Est. completion date: December 31, 2017

Study information

• Verified date: March 2018
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to systematically Analyse the metabolome in capillary blood of healthy men and women at rest and during defined standardized physical activity under normobaric normoxia or hypoxia with a specific focus on metabolites and metabolic pattern related to energy metabolism. The metabolome analyses in capillary blood could give us also or more detailed insight into erythrocyte metabolic physiology because it is known for a longer time that the primary metabolism of the erythrocyte reflects its Oxygen Saturation via the glycolytic metabolites / intermediates pattern.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: December 31, 2017
• Est. primary completion date: March 31, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• healthy volunteers

• written informed consent

Exclusion Criteria:

• known cardio-vascular, lung, metabolic, endocrine, hematologic, kidney or neurologic diseases

• pregnancy, lactating period

• unability to understand study content and aims and to give written informed consent

Related Conditions & MeSH terms

• Healthy Men and Women

Intervention

Other:
• running on a treadmill under normoxia or hypoxia
30 min running (60% VO2max) on a treadmill under hypoxia (O2: 14%) 30 min running (60% VO2max) on a treadmill under normoxia (O2: 20%)

Locations

Country	Name	City	State
Germany	Charite University Medicine, ECRC	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in capillary lactate/pyruvate Ratio (dimension-free)	marker for the ratio between anaerobic / aerobic glycolysis	t = 0 min (before exercise); t = 10, 20 and 30 min during exercise; t = 50 and 60 min during recovery