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Healthy Male Volunteers clinical trials

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NCT ID: NCT03014895 Completed - Clinical trials for Healthy Male Volunteers

A Single Intravenous Dose Study of E3112 in Japanese Healthy Adult Male Subjects

Start date: January 25, 2017
Phase: Early Phase 1
Study type: Interventional

The study (E3112/CP1) is a single-center, randomized, double-blind, placebo-controlled, single intravenous ascending dose study conducted in Japanese healthy adult males to evaluate the pharmacokinetics (PK), safety, and immunogenicity of E3112 following a single intravenous dose of E3112.

NCT ID: NCT02250976 Completed - Clinical trials for Healthy Male Volunteers

The Pharmacokinetic Study of the Fixed-dose Combination of Micronized Fenofibrate and Pitavastatin Ca

Start date: September 2014
Phase: Phase 1
Study type: Interventional

To evaluate the comparative pharmacokinetics and safety of fixed-dose combination versus coadministration of Lipilfen cap.160mg(micronized fenofibrate160mg) and Livalo tab. 2mg(pitavastatin Ca 2mg) under fed condition in healthy male volunteers.

NCT ID: NCT01965301 Terminated - Clinical trials for Healthy Male Volunteers

First-time-in-man, to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BP1.5375

Start date: October 2014
Phase: Phase 1
Study type: Interventional

Phase I Single Ascending Dose (Part 1), phase IIa Proof Of Concept (Part 2)

NCT ID: NCT01948011 Completed - Clinical trials for Healthy Male Volunteers

Racecadotril Suspension Linearity Study & Comparative Bioavailability Versus Granules

Start date: September 2013
Phase: Phase 1
Study type: Interventional

To investigate the Racecadotril pharmacokinetic linearity after single oral administration of 10, 30 and 60 mg as a suspension. To evaluate the comparative bioavailability of the new Racecadotril formulation (suspension) versus the reference sachet formulation (granules)

NCT ID: NCT01939639 Completed - Clinical trials for Healthy Male Volunteers

The Influence of Oxytocin on the Processing of Social Contact

Start date: March 2013
Phase: Phase 1
Study type: Interventional

Social touch can convey the most potent and salient of socio-emotional signals. While the hypothalamic peptide oxytocin (OXT) has been identified as a key neurochemical mediator of grooming in some other social species, its modulatory influence on human interpersonal touch is unknown. The investigators expect that OXT augments the hedonic value of touch and that this behavioral effect is paralleled at the neural level by an increased response in brain areas mediating rewarding aspects of social touch.

NCT ID: NCT01871844 Completed - Clinical trials for Healthy Male Volunteers

ITF2984 Repeated Doses Study in Healthy Volunteers

MAD
Start date: January 2012
Phase: Phase 1
Study type: Interventional

This was a within group, randomised, repeated dose, placebo- and octreotide controlled study in a target population of 45 healthy male subjects. Subjects were required to attend the clinical for screening procedures between 3 and 28 days before dosing commenced. The study was conducted in 4 groups of subjects; Groups 1 to 3 were a double-blinded, randomised design, each consisting of 12 subjects. Group 4 was an open-label design and consisted of 9 subjects. There was a minimum interval of 96 h between dosing of Groups 1, 2 and 3 to allow for interim analyses of PK and safety/tolerability data for dose escalation purposes. Group 4 (the active control group) was still to proceed if the decision was taken to prematurely stop dosing with ITF2984 (somatostatin analogue) following review of the PK and safety data presented at the interim decision meeting; dosing of this group was conducted independently from Groups 1 to 3. On Days 1 to 6, subjects in Groups 1 to 3 were to receive 2 doses of investigational medicinal product (IMP) approximately 12 h apart; subjects in Group 4 were to receive 3 doses of IMP approximately 8 h apart. For all groups, subjects were scheduled to receive their final dose of IMP on the morning of Day 7. In addition, subjects were to receive exogenous test administrations(stimulation test) on Day -1, Day 1 and Day 7 at the same time on each day (ie for Day -1, 23.5 h before the first dose of IMP, and for Days 1 and 7, 0.5 h after the first dose of IMP on the respective day). Blood samples for PD and PK analyses were taken at specified time points after each dosing. Subjects remained on site for 10 days (ie 36 h after the final dose of IMP on Day 7) providing that discharge conditions had been met, and returned to the clinic between 5 and 10 days after the last IMP administration for a follow-up visit.

NCT ID: NCT01767610 Completed - Clinical trials for Healthy Male Volunteers

Evaluation of Pharmacokinetic Interaction Between Micronized Fenofibrate and Pitavastatin

Start date: January 2013
Phase: Phase 1
Study type: Interventional

To evaluate pharmacokinetic drug interaction by comparing the steady-state pharmacokinetic characteristics of each arms after repeated administrating Lipilfen cap. 160mg and Livalo tab. 2mg through 3 period by separately or combinedly.

NCT ID: NCT01731275 Completed - Clinical trials for Healthy Male Volunteers

A Phase 1 Single Dose Study of E6011 in Japanese Healthy Adult Male Subjects (Study E6011-J081-001)

Start date: August 2012
Phase: Phase 1
Study type: Interventional

To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose (SAD) administration of E6011 in Japanese healthy volunteers.

NCT ID: NCT01607970 Completed - Clinical trials for Healthy Male Volunteers

Oxytocin Modulation of Startle Reactivity to Social Stimuli and Moral Decision Making

Start date: August 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether oxytocin affects the modulation of startle reactivity by aversive social stimuli and to investigate the oxytocin effect on moral judgements. Furthermore the investigators explore the effects of oxytocin receptor (OXTR) polymorphisms on behavioral responses to social stimuli.

NCT ID: NCT01606462 Completed - Clinical trials for Healthy Male Volunteers

Oxytocin and Social Cognition

Start date: June 2011
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether oxytocin influences memory of social stimuli and reaction to social stimuli. Furthermore the investigators explore the effect of oxytocin receptor (OXTR) polymorphism in terms of behavioral and neural responses to social stimuli.