The Effect of Caffeine in Elderly Citizens

Healthy Elderly Citizens Clinical Trial

Official title:

The Effect of Caffeine as Endurance Enhancing Drug in the Elderly

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00117520
• Other study ID #: 2612-1987
• Status: Completed
• Phase: Phase 4
• First received: June 30, 2005
• Last updated: July 3, 2006
• Start date: July 2002
• Est. completion date: March 2006

Study information

• Verified date: July 2002
• Source: Herning Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: National Board of Health
• Study type: Interventional

Clinical Trial Summary

The study investigated the effect of caffeine on physical performance in healthy citizens aged over 70 years. The main hypothesis was that 6 mg/kg caffeine would improve cycling endurance at 65% of expected maximal heart rate.

Description:

Caffeine ingestion increases the endurance of young people exercising at 60%-85% of their maximal oxygen uptake, and it also seems to improve endurance as measured by repeated sub-maximal isometric contraction and decreases the rate of perceived exertion during exercise. Although caffeine increases endurance in young people, an increase in endurance may be of greater interest in the elderly as the population of older adults with a physically active lifestyle is growing rapidly or for increasing endurance fitness through an exercise or rehabilitation program. Therefore the main hypothesis was that caffeine would improve cycling endurance at 65% of expected maximal heart rate, and the secondary hypotheses were that caffeine would improve postural stability, reaction and movement times, isometric arm flexion endurance, and walking speed, and would reduce the rate of perceived exertion after 5 minutes of cycling in healthy elderly citizens.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: March 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• Healthy elderly individuals aged over 70 years

Exclusion Criteria:

• Dementia or invalidating psychiatric disease

• General debility, angina, or other diseases that would render participation in the test program impossible

• Treatment with beta receptor blocking drugs, calcium-channel blocking drugs, digitalis, or nitroglycerine

• Acute disease and injury

• Diabetes

• Conditions that would contraindicate caffeine ingestion or participation in the test program

• Treatment with medication that interacts with caffeine

• Ingestion of caffeine containing drinks and foods 48 hours before each session

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy Elderly Citizens

Intervention

Drug:
• Caffeine

Locations

Country	Name	City	State
Denmark	Surgical Research Department	Herning	Ringkjoebing

Sponsors (1)

Lead Sponsor	Collaborator
Herning Hospital

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	endurance measured on an ergometer bicycle
Secondary	postural stability
Secondary	reactiontime
Secondary	isometric endurance (armflexion)
Secondary	walking speed
Secondary	fatigue