Serotonin and Motor Plasticity

Healthy Controls Clinical Trial

Official title: The Effects of Serotonergic Challenge on Motor Learning and Neuroplasticity

Status Recruiting

Clinical Trial Summary

With this study, the investigators aim to test whether acute administration of selective serotonin reuptake inhibitors (SSRI) improves motor performance in a sequential motor learning task in comparison to placebo in healthy humans.

Clinical Trial Description

Microdialysis findings in animal models provide evidence for a monoaminergic augmentation of motor function. However, this evidence is largely limited to noradrenaline and dopamine, with little evidence to support a similar effect for serotonin. What remains to be tested therefore, is whether acute serotonergic administration induces neural or behavioral changes during motor learning also. Using a sample of 60 female participants (with the possible inclusion of male participants at a later date), the investigators aim to test the effects of a serotonergic challenge on motor learning and plasticity in healthy participants. ;

Related Conditions & MeSH terms

• Healthy Controls

• NCT number: NCT03162185
• Study type: Interventional
• Source: Max Planck Institute for Human Cognitive and Brain Sciences
• Contact: Alyson Buchenau
• Phone: +49-341-9940-2216
• Email: buchenau@cbs.mpg.de
• Status: Recruiting
• Phase: Phase 4
• Start date: April 1, 2017
• Completion date: November 30, 2017