Diet Induced Intestinal Mucosal Adaptation

Healthy Conditions Clinical Trial

Official title: Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates

Status Completed

Clinical Trial Summary

Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Healthy Conditions

• NCT number: NCT02088853
• Study type: Interventional
• Source: Göteborg University
• Status: Completed
• Phase: N/A
• Start date: March 2014
• Completion date: December 2014