The Effects of Post Aerobic Exercise Hot Water Immersion on Physiological and Perceptual Responses in Physically Inactive Middle-aged Adults

Healthy Aging Clinical Trial

Official title:

The Effects of Post Aerobic Exercise Hot Water Immersion on Physiological and Perceptual Responses in Physically Inactive Middle-aged Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05035004
• Other study ID #: P97102
• Status: Completed
• Phase: N/A
• Start date: November 15, 2021
• Est. completion date: March 16, 2022

Study information

• Verified date: March 2022
• Source: Coventry University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will investigate the effects of post moderate intensity aerobic exercise hot water immersion on physiological and perceptual responses in physically inactive middle-aged adults when compared to moderate intensity aerobic exercise and hot water immersion alone.

Description:

A large number of middle aged adults do not achieve the minimum recommended amount of physical activity. This consequently increases the risk of cardiovascular disease and all-cause mortality. Although below the recommended physical activity guidelines, it is important to highlight that a considerable proportion of these individuals do take part in some form of physical activity within their weekly routines. Hence, identifying complementary therapies that can enhance the health benefits from smaller amounts of exercise are of great value for many physically inactive middle-aged adults.

An in increase in body temperature from a single session of passive heating has been shown to mimic many of the beneficial physiological responses of exercise, such as, an increase in heart rate, skin blood flow and an increase in circulating angiogenic factors. However, lab based studies often push participants to the limit of thermal tolerance which may reduce long term adherence in the real world. Therefore, this study will investigate whether the use of post exercise hot water immersion can prolong and / or intensify exercise mediated physiological responses that underpin health benefits, whilst also assessing the perceptual responses, in comparison to exercise and hot water immersion alone.

Through the use of a repeated measures design, participants will randomly take part in three conditions; 1) post exercise hot water immersion (30 minutes of moderate intensity cycling followed by 10 minutes of supine rest and 30 minutes of whole body hot water immersion at 40°C); 2) aerobic exercise (30 minutes of moderate intensity cycling followed by 10 minutes of supine rest and 30 minutes of seated rest at room temperature); 3) hot water immersion condition (30 minutes of whole body hot water immersion at 40°C followed by 10 minutes of supine rest and 30 minutes of whole body hot water immersion at 40°C). Each condition will be separated by a minimum of 1-week. Outcome measures will either be assessed at regular intervals or at 0, 30, 70 and 100 minute time points for each condition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: March 16, 2022
• Est. primary completion date: March 16, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 40 Years to 60 Years

Eligibility

Inclusion Criteria:

• Males and post menopausal females

• Aged between 40 - 60 years

• BMI of 18.5 - 34.9 kg/m2

• Over the last 6 months has participated in less than 150 mins of moderate intensity physical activity or 75 mins of vigorous activity or a combination of both, but takes part in some form of physical activity within their weekly routine.

• Maximal oxygen uptake categorised as 'fair' for a given age group.

Exclusion Criteria:

• Previous myocardial infarction or cerebrovascular event

• Any signs or symptoms of cardiovascular issues

• High blood pressure: SBP >180 mmHg and / or DBP >100 mmHg

• Orthostatic hypotension: Drop of SBP > 20mmHg and / or DBP >10 mmHg upon standing.

• Changed blood pressure medication in the 6-month period prior to the study

• Plan to change any form of relevant medication during study period

• Suffers from diabetes

• Suffers from severe asthma

• Currently have any infections or symptoms of an infection (e.g. COVID-19 etc)

• Suffers from a neurodegenerative disease

• Cannot understand and/or fully cooperate with the study protocol

• Exercise-limiting comorbidity (e.g. angina, chronic lung disease, arthritis etc)

• Severe peripheral neuropathy (cannot sense temperature)

• Current smoker or have stopped in the last 3 months

• Any skin conditions including ulcerations

• Exposed to high temperatures in the last 4-weeks (e.g. holiday, spa, sun beds etc)

• Use of antioxidant supplements in the last 6-weeks

Related Conditions & MeSH terms

• Healthy Aging

Intervention

Device:
• Post exercise hot water immersion
Participants will complete 30 minutes of cycling on a lode bicycle ergometer (50% of VO2max), followed by a 10-minute transfer period and then 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C).
• Exercise
Participants will complete 30 minutes of cycling on a lode bicycle ergometer (50% of VO2max).
• Hot water immersion
Participants will complete 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C), followed by a 10-minute transfer period and then an additional 30 minutes of whole-body hot water immersion in a hot tub (water temperature 40°C).

Locations

Country	Name	City	State
United Kingdom	Coventry University	Coventry	West Midlands

Sponsors (1)

Lead Sponsor	Collaborator
Coventry University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in rectal core temperature (°C)	Measured using a rectal probe attached to a squirrel data logger	Measurements taken at 10 minute intervals up to 100 minutes
Other	Change in forehead skin temperature (°C)	Measured using skin thermistors attached to a squirrel data logger	Measurements taken at 10 minute intervals up to 100 minutes
Other	Change in heart rate (bpm)	Measured using a heart rate monitor	Measurements taken at 10 minute intervals up to 100 minutes
Other	Change in plasma volume (%)	Measured by a capillary blood sample then calculating plasma volume via the hemoglobin and hematocrit	Measurements taken pre and immediately post intervention
Primary	Change in circulating plasma nitrite (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery total shear rate (S-1)	Terason ultrasound recording of the brachial and superficial femoral artery	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery antegrade shear rate (S-1)	Terason ultrasound recording of the brachial and superficial femoral artery.	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery retrograde shear rate (S-1)	Terason ultrasound recording of the brachial and superficial femoral artery	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery diameter (mm)	Terason ultrasound recording of the brachial and superficial femoral artery	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery blood flow (ml/min)	Terason ultrasound recording of the brachial and superficial femoral artery.	Measured at 0, 30, 70 and 100 minutes
Primary	Change in brachial artery compliance (µm/mmHg)	Terason ultrasound recording of the brachial artery. Brachial artery compliance will be calculated by using the change in blood volume and blood pressure	Measured at 0, 30, 70 and 100 minutes
Primary	Change in systolic blood pressure (mmHg)	Measured using an automated blood pressure cuff	Measurements taken at 10 minute intervals up to 100 minutes
Primary	Change in diastolic blood pressure (mmHg)	Measured using an automated blood pressure cuff	Measurements taken at 10 minute intervals up to 100 minutes
Primary	Change in mean arterial pressure (mmHg)	Measured using an automated blood pressure cuff. Mean arterial pressure will be calculated by using systolic and diastolic blood pressure	Measurements taken at 10 minute intervals up to 100 minutes
Primary	Change in pulse pressure (mmHg)	Measured using an automated blood pressure cuff. Pulse pressure will be calculated using systolic and diastolic blood pressure	Measurements taken at 10 minute intervals up to 100 minutes
Secondary	Change in circulating serum Interleukin-6 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Interleukin-10 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Interleukin-8 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Interleukin-1Ra (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Vascular endothelial growth factor (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Endothelin-1 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Circulating serum Monocyte chemoattractant protein-1 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Matrix metallopeptidase-2 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Change in circulating serum Matrix metallopeptidase-9 (pg/ml)	Venous blood sample	Measured at 0, 30, 70 and 100 minutes
Secondary	Energy expenditure (kcal/h-1)	Measured initially by breath by breath analysis through the use of a Ultima and calculated via indirect calorimetry	Gas measurements taken continually up to 70 minutes. Energy expenditure calculated from the 30 minutes of exercise, hot water immersion and/or rest periods.
Secondary	Change in thermal comfort	Thermal comfort Likert scale from a positive score of +5 very comfortable (maximum) to a negative score of -5 very uncomfortable (minimum)	Measured at 10 minute intervals up to 100 minutes
Secondary	Change in thermal sensation	Thermal sensation Likert scale from +5 (maximum) hot to -5 cold (minimum)	Measured at 10 minute intervals up to 100 minutes
Secondary	Change in basic affect	Basic affect Likert scale from a positive score of +5 very good (maximum) to a negative score of -5 very bad (minimum)	Measured at 10 minute intervals up to 100 minutes
Secondary	Change in physical activity enjoyment scale	Feelings about exercise and / or passive heating on a Likert scale from a positive score of 1 (maximum) to a negative score of 7 (minimum)	Measured ~12 minutes post intervention