Virtual Reality Study - COVID-19 Protocol

Healthy Aging Clinical Trial

— NRVR  

Official title:

Targeted Physical and Cognitive Activity in a VR Environment - COVID-19 Protocol

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04678778
• Other study ID #: HS17-00354
• Status: Completed
• Phase: N/A
• Start date: March 19, 2019
• Est. completion date: February 19, 2021

Study information

• Verified date: April 2021
• Source: University of Southern California
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overarching goal of this pilot clinical trial is to use a novel virtual reality (VR)-based intervention that simultaneously engages physical and cognitive activity aimed at improving brain and cognitive outcomes in older adults. Physical activity is a promising lifestyle intervention for mitigating cognitive decline or delaying onset of dementia. However, to fully leverage beneficial brain effects of physical activity, training the brain to learn and engage in a cognitively stimulating environment may be the key to enhanced brain and cognitive outcomes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: February 19, 2021
• Est. primary completion date: February 19, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 85 Years

Eligibility

Inclusion Criteria:

• 50-85 Years Old

• Able to Walk Without Assistance

• Fluent in English

• No Ferromagnetic Metal in Body

• Able to Participate in Moderate Aerobic Physical Activity

Exclusion Criteria:

• Severe Brain Injury/ Head Trauma

• Pacemakers or Metal Implants

• Claustrophobia

• Contradictions to Magnetic Resonance Imaging (MRI)/ Positron Emission Tomography (PET) Brain Scans

• Opposition to Blood Draws

Related Conditions & MeSH terms

• Healthy Aging

Intervention

Behavioral:
• Physical and Cognitive Activity
There are three sessions a week for the course of 12 weeks. Each session consists of 5 trials.

Locations

Country	Name	City	State
United States	Mark and Mary Stevens Neuroimaging and Informatics Institute of the University of Southern California	Los Angeles	California

Sponsors (1)

Lead Sponsor	Collaborator
University of Southern California

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Magnetic Resonance Image (MRI) brain scan of hippocampal volume (cubic mm)	The hippocampus has been shown to be a selectively vulnerable region in Alzheimer's Disease (AD), and several studies, including our own, identified a dysfunctional brain signal in the hippocampus in Mild Cognitive Impairment (MCI) patients. We propose to examine the effects of exercise on remediating this hyperactive signal exhibited in MCI patients.	12 weeks
Primary	Mnemonic Similarity Task for visual memory performance - discrimination index	With the study's primary focus on hippocampal function, we will use the Mnemonic Separation Task (MST), a hippocampus-dependent discrimination test of similar objects, as our primary cognitive outcome.	12 weeks