Healthy Aging Clinical Trial
Official title:
Impact of Short-term Intensive Online Grammatical Reasoning Training on Cognition and Function in Adults Over 50: An Online Randomised Controlled Trial
The START study will investigate the impact of playing a Grammatical Reasoning brain training
task on overall brain function (cognition) and day-to-day function in people over 50.
The study builds on existing work that has shown very promising results with brain training
approaches in older adults. There is good evidence that playing brain training games leads to
improvements in brain functions including memory and reasoning. There is also a suggestion
that regular involvement in brain training games might help reduce the risk of cognitive
decline and dementia later in life. It appears that reasoning, or problem-solving, is
particularly important as it is one of the first abilities to decline with age. This study
will use this evidence to target reasoning in a specific brain training task. It will also
explore the potential role of genetic factors in how people perform in the task.
The study will compare the impact of a Grammatical Reasoning Task (START) with a control task
consisting of simple picture-matching. Over 7000 participants will be randomly allocated to
either START or the control and will be asked to play the task as often as they wish for a
period of six weeks. Both tasks will be delivered entirely online so people will access the
study from home on their computers. This will be achieved through our dedicated online
research platform, PROTECT, which hosts a cohort of over 20,000 older adults who have
provided DNA samples as part of a longitudinal study.
This study will measure the impact of the training on cognition and Instrumental Activities
of Daily Living. Assessments will be completed online at baseline, two/six weeks and six
months. Overall, this study aims to generate exciting new data about how brain training could
be included in guidance on healthy ageing.
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